Anxiolytic effects of cytotoxic hippocampal lesions in rats.
Rats with cytotoxic lesions of the hippocampus were given 3 anxiety tests: social interaction with a novel rat, the elevated zero-maze (a modification of the plus-maze), and hyponeophagia (eating familiar and novel foods in a novel place). Marked anxiolytic effects were seen in the social interactio...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2002
|
| _version_ | 1826275287928668160 |
|---|---|
| author | Deacon, R Bannerman, D Rawlins, J |
| author_facet | Deacon, R Bannerman, D Rawlins, J |
| author_sort | Deacon, R |
| collection | OXFORD |
| description | Rats with cytotoxic lesions of the hippocampus were given 3 anxiety tests: social interaction with a novel rat, the elevated zero-maze (a modification of the plus-maze), and hyponeophagia (eating familiar and novel foods in a novel place). Marked anxiolytic effects were seen in the social interaction and hyponeophagia tests, but not on the zero-maze. These results confirm and extend previous experiments that used traditional lesion techniques. The zero-maze result was consistent with other experiments using the plus-maze, in which intrahippocampal administrations of pharmacological agents were not anxiolytic, although variability in ethological tests may also be a factor. As the hyponeophagia test used an elevated apparatus, as in the zero- and plus-mazes, the lack of a lesion effect in the zero-maze was unlikely to have been due to an inability to relieve height-induced anxiety. |
| first_indexed | 2024-03-06T22:56:25Z |
| format | Journal article |
| id | oxford-uuid:608bb800-9f8d-426b-92d4-6ea33492d614 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:56:25Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:608bb800-9f8d-426b-92d4-6ea33492d6142022-03-26T17:54:03ZAnxiolytic effects of cytotoxic hippocampal lesions in rats.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:608bb800-9f8d-426b-92d4-6ea33492d614EnglishSymplectic Elements at Oxford2002Deacon, RBannerman, DRawlins, JRats with cytotoxic lesions of the hippocampus were given 3 anxiety tests: social interaction with a novel rat, the elevated zero-maze (a modification of the plus-maze), and hyponeophagia (eating familiar and novel foods in a novel place). Marked anxiolytic effects were seen in the social interaction and hyponeophagia tests, but not on the zero-maze. These results confirm and extend previous experiments that used traditional lesion techniques. The zero-maze result was consistent with other experiments using the plus-maze, in which intrahippocampal administrations of pharmacological agents were not anxiolytic, although variability in ethological tests may also be a factor. As the hyponeophagia test used an elevated apparatus, as in the zero- and plus-mazes, the lack of a lesion effect in the zero-maze was unlikely to have been due to an inability to relieve height-induced anxiety. |
| spellingShingle | Deacon, R Bannerman, D Rawlins, J Anxiolytic effects of cytotoxic hippocampal lesions in rats. |
| title | Anxiolytic effects of cytotoxic hippocampal lesions in rats. |
| title_full | Anxiolytic effects of cytotoxic hippocampal lesions in rats. |
| title_fullStr | Anxiolytic effects of cytotoxic hippocampal lesions in rats. |
| title_full_unstemmed | Anxiolytic effects of cytotoxic hippocampal lesions in rats. |
| title_short | Anxiolytic effects of cytotoxic hippocampal lesions in rats. |
| title_sort | anxiolytic effects of cytotoxic hippocampal lesions in rats |
| work_keys_str_mv | AT deaconr anxiolyticeffectsofcytotoxichippocampallesionsinrats AT bannermand anxiolyticeffectsofcytotoxichippocampallesionsinrats AT rawlinsj anxiolyticeffectsofcytotoxichippocampallesionsinrats |