Amino acid sensing by mTORC1: intracellular transporters mark the spot
Cell metabolism and growth are matched to nutrient availability via the amino-acid-regulated mechanistic target of rapamycin complex 1 (mTORC1). Transporters have emerged as important amino acid sensors controlling mTOR recruitment and activation at the surface of multiple intracellular compartments...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Published: |
Elsevier
2016
|
| _version_ | 1797071653974310912 |
|---|---|
| author | Goberdhan, D Wilson, C Harris, A |
| author_facet | Goberdhan, D Wilson, C Harris, A |
| author_sort | Goberdhan, D |
| collection | OXFORD |
| description | Cell metabolism and growth are matched to nutrient availability via the amino-acid-regulated mechanistic target of rapamycin complex 1 (mTORC1). Transporters have emerged as important amino acid sensors controlling mTOR recruitment and activation at the surface of multiple intracellular compartments. Classically, this has involved late endosomes and lysosomes, but now, in a recent twist, also the Golgi apparatus. Here we propose a model in which specific amino acids in assorted compartments activate different mTORC1 complexes, which may have distinct drug sensitivities and functions. We will discuss the implications of this for mTORC1 function in health and disease. |
| first_indexed | 2024-03-06T22:56:29Z |
| format | Journal article |
| id | oxford-uuid:6091e4af-a2c6-4d00-930e-150205455c23 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T22:56:29Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:6091e4af-a2c6-4d00-930e-150205455c232022-03-26T17:54:10ZAmino acid sensing by mTORC1: intracellular transporters mark the spotJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6091e4af-a2c6-4d00-930e-150205455c23Symplectic Elements at OxfordElsevier2016Goberdhan, DWilson, CHarris, ACell metabolism and growth are matched to nutrient availability via the amino-acid-regulated mechanistic target of rapamycin complex 1 (mTORC1). Transporters have emerged as important amino acid sensors controlling mTOR recruitment and activation at the surface of multiple intracellular compartments. Classically, this has involved late endosomes and lysosomes, but now, in a recent twist, also the Golgi apparatus. Here we propose a model in which specific amino acids in assorted compartments activate different mTORC1 complexes, which may have distinct drug sensitivities and functions. We will discuss the implications of this for mTORC1 function in health and disease. |
| spellingShingle | Goberdhan, D Wilson, C Harris, A Amino acid sensing by mTORC1: intracellular transporters mark the spot |
| title | Amino acid sensing by mTORC1: intracellular transporters mark the spot |
| title_full | Amino acid sensing by mTORC1: intracellular transporters mark the spot |
| title_fullStr | Amino acid sensing by mTORC1: intracellular transporters mark the spot |
| title_full_unstemmed | Amino acid sensing by mTORC1: intracellular transporters mark the spot |
| title_short | Amino acid sensing by mTORC1: intracellular transporters mark the spot |
| title_sort | amino acid sensing by mtorc1 intracellular transporters mark the spot |
| work_keys_str_mv | AT goberdhand aminoacidsensingbymtorc1intracellulartransportersmarkthespot AT wilsonc aminoacidsensingbymtorc1intracellulartransportersmarkthespot AT harrisa aminoacidsensingbymtorc1intracellulartransportersmarkthespot |