New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated bo...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2013
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| _version_ | 1826275296342441984 |
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| author | Horikoshi, M Yaghootkar, H Mook-Kanamori, DO Sovio, U Taal, H Hennig, B Bradfield, J St Pourcain, B Evans, D Charoen, P Kaakinen, M Cousminer, D Lehtimäki, T Kreiner-Møller, E Warrington, N Bustamante, M Feenstra, B Berry, D Thiering, E Pfab, T Barton, S Shields, B Kerkhof, M van Leeuwen, E Fulford, A |
| author_facet | Horikoshi, M Yaghootkar, H Mook-Kanamori, DO Sovio, U Taal, H Hennig, B Bradfield, J St Pourcain, B Evans, D Charoen, P Kaakinen, M Cousminer, D Lehtimäki, T Kreiner-Møller, E Warrington, N Bustamante, M Feenstra, B Berry, D Thiering, E Pfab, T Barton, S Shields, B Kerkhof, M van Leeuwen, E Fulford, A |
| author_sort | Horikoshi, M |
| collection | OXFORD |
| description | Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. |
| first_indexed | 2024-03-06T22:56:33Z |
| format | Journal article |
| id | oxford-uuid:609856b3-9440-4181-b850-f4eea1e9c36c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:56:33Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:609856b3-9440-4181-b850-f4eea1e9c36c2022-03-26T17:54:19ZNew loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:609856b3-9440-4181-b850-f4eea1e9c36cEnglishSymplectic Elements at Oxford2013Horikoshi, MYaghootkar, HMook-Kanamori, DOSovio, UTaal, HHennig, BBradfield, JSt Pourcain, BEvans, DCharoen, PKaakinen, MCousminer, DLehtimäki, TKreiner-Møller, EWarrington, NBustamante, MFeenstra, BBerry, DThiering, EPfab, TBarton, SShields, BKerkhof, Mvan Leeuwen, EFulford, ABirth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. |
| spellingShingle | Horikoshi, M Yaghootkar, H Mook-Kanamori, DO Sovio, U Taal, H Hennig, B Bradfield, J St Pourcain, B Evans, D Charoen, P Kaakinen, M Cousminer, D Lehtimäki, T Kreiner-Møller, E Warrington, N Bustamante, M Feenstra, B Berry, D Thiering, E Pfab, T Barton, S Shields, B Kerkhof, M van Leeuwen, E Fulford, A New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. |
| title | New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. |
| title_full | New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. |
| title_fullStr | New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. |
| title_full_unstemmed | New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. |
| title_short | New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. |
| title_sort | new loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism |
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