A summary of the iodine supplementation study protocol (I2S2): a UK multicentre randomised controlled trial in preterm infants.
This paper summarises the study protocol for the randomised controlled trial of iodine supplementation in preterm infants. Iodine is essential for the synthesis of thyroxine, and thyroxine is essential for normal brain development in utero and for the first 2-3 years of life. The recommended iodine...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2014
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| _version_ | 1797071665431052288 |
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| author | Williams, F Hume, R Ogston, S Brocklehurst, P Morgan, K Juszczak, E |
| author_facet | Williams, F Hume, R Ogston, S Brocklehurst, P Morgan, K Juszczak, E |
| author_sort | Williams, F |
| collection | OXFORD |
| description | This paper summarises the study protocol for the randomised controlled trial of iodine supplementation in preterm infants. Iodine is essential for the synthesis of thyroxine, and thyroxine is essential for normal brain development in utero and for the first 2-3 years of life. The recommended iodine intake in parenteral nutrition regimens is 1 μg/kg/day and commercially available parenteral solutions for infants reflect these recommendations. In the absence of other iodine sources, infants are vulnerable to negative iodine balance and insufficiency. As many preterm infants are fed parenterally for prolonged periods with solutions which have been shown to be iodine-deficient, the I2S2 Trial was designed to establish whether iodine supplementation of preterm infants benefits neurodevelopment. |
| first_indexed | 2024-03-06T22:56:39Z |
| format | Journal article |
| id | oxford-uuid:60a100b6-1d61-468e-8a8a-0afa39fb8e2a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:56:39Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:60a100b6-1d61-468e-8a8a-0afa39fb8e2a2022-03-26T17:54:29ZA summary of the iodine supplementation study protocol (I2S2): a UK multicentre randomised controlled trial in preterm infants.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:60a100b6-1d61-468e-8a8a-0afa39fb8e2aEnglishSymplectic Elements at Oxford2014Williams, FHume, ROgston, SBrocklehurst, PMorgan, KJuszczak, EThis paper summarises the study protocol for the randomised controlled trial of iodine supplementation in preterm infants. Iodine is essential for the synthesis of thyroxine, and thyroxine is essential for normal brain development in utero and for the first 2-3 years of life. The recommended iodine intake in parenteral nutrition regimens is 1 μg/kg/day and commercially available parenteral solutions for infants reflect these recommendations. In the absence of other iodine sources, infants are vulnerable to negative iodine balance and insufficiency. As many preterm infants are fed parenterally for prolonged periods with solutions which have been shown to be iodine-deficient, the I2S2 Trial was designed to establish whether iodine supplementation of preterm infants benefits neurodevelopment. |
| spellingShingle | Williams, F Hume, R Ogston, S Brocklehurst, P Morgan, K Juszczak, E A summary of the iodine supplementation study protocol (I2S2): a UK multicentre randomised controlled trial in preterm infants. |
| title | A summary of the iodine supplementation study protocol (I2S2): a UK multicentre randomised controlled trial in preterm infants. |
| title_full | A summary of the iodine supplementation study protocol (I2S2): a UK multicentre randomised controlled trial in preterm infants. |
| title_fullStr | A summary of the iodine supplementation study protocol (I2S2): a UK multicentre randomised controlled trial in preterm infants. |
| title_full_unstemmed | A summary of the iodine supplementation study protocol (I2S2): a UK multicentre randomised controlled trial in preterm infants. |
| title_short | A summary of the iodine supplementation study protocol (I2S2): a UK multicentre randomised controlled trial in preterm infants. |
| title_sort | summary of the iodine supplementation study protocol i2s2 a uk multicentre randomised controlled trial in preterm infants |
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