Immunogenetics and genomics.
Immunogenetic analysis of disease susceptibility has been encouraged by the identification of strong HLA associations with several diseases of uncertain cause. Weaker HLA associations exist with a large number of infectious and non-infectious diseases and the mechanisms of these effects are beginnin...
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| Format: | Journal article |
| Language: | English |
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2001
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| _version_ | 1797071667400278016 |
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| author | Hill, A |
| author_facet | Hill, A |
| author_sort | Hill, A |
| collection | OXFORD |
| description | Immunogenetic analysis of disease susceptibility has been encouraged by the identification of strong HLA associations with several diseases of uncertain cause. Weaker HLA associations exist with a large number of infectious and non-infectious diseases and the mechanisms of these effects are beginning to be uncovered. Extensive analyses of non-HLA immunogenetic variants have also been undertaken and associations with a variety of genes identified. Genetic linkage analysis of multicase families has recently identified new major susceptibility loci for a few immunologically determined common diseases. However, the greatest potential for the future lies in genome-wide searches for susceptibility genes that individually might have quite modest effects but cumulatively have a large impact on individual risk. This new era of immunogenomics promises to provide key insights into disease pathogenesis and identify multiple molecular targets for intervention strategies. |
| first_indexed | 2024-03-06T22:56:41Z |
| format | Journal article |
| id | oxford-uuid:60a34cbb-0c1f-4be1-8412-fc41a65a2ef2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:56:41Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:60a34cbb-0c1f-4be1-8412-fc41a65a2ef22022-03-26T17:54:34ZImmunogenetics and genomics.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:60a34cbb-0c1f-4be1-8412-fc41a65a2ef2EnglishSymplectic Elements at Oxford2001Hill, AImmunogenetic analysis of disease susceptibility has been encouraged by the identification of strong HLA associations with several diseases of uncertain cause. Weaker HLA associations exist with a large number of infectious and non-infectious diseases and the mechanisms of these effects are beginning to be uncovered. Extensive analyses of non-HLA immunogenetic variants have also been undertaken and associations with a variety of genes identified. Genetic linkage analysis of multicase families has recently identified new major susceptibility loci for a few immunologically determined common diseases. However, the greatest potential for the future lies in genome-wide searches for susceptibility genes that individually might have quite modest effects but cumulatively have a large impact on individual risk. This new era of immunogenomics promises to provide key insights into disease pathogenesis and identify multiple molecular targets for intervention strategies. |
| spellingShingle | Hill, A Immunogenetics and genomics. |
| title | Immunogenetics and genomics. |
| title_full | Immunogenetics and genomics. |
| title_fullStr | Immunogenetics and genomics. |
| title_full_unstemmed | Immunogenetics and genomics. |
| title_short | Immunogenetics and genomics. |
| title_sort | immunogenetics and genomics |
| work_keys_str_mv | AT hilla immunogeneticsandgenomics |