Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers
Background: We chose a set of candidate single nucleotide polymorphisms (SNPs) to investigate gene-environment interactions in three types of cancer that have been related to air pollution (lung, bladder and myeloid leukemia). Patients and methods: The study has been conducted as a nested case-contr...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1797071670763061248 |
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| author | Vineis, P Veglia, F Garte, S Malaveille, C Matullo, G Dunning, A Peluso, M Airoldi, L Overvad, K Raaschou-Nielsen, O Clavel-Chapelon, F Linseisen, J Kaaks, R Boeing, H Trichopoulou, A Palli, D Crosignani, P Tumino, R Panico, S Bueno-De-Mesquita, H Peeters, P Lund, E Gonzalez, C Martinez, C Dorronsoro, M |
| author_facet | Vineis, P Veglia, F Garte, S Malaveille, C Matullo, G Dunning, A Peluso, M Airoldi, L Overvad, K Raaschou-Nielsen, O Clavel-Chapelon, F Linseisen, J Kaaks, R Boeing, H Trichopoulou, A Palli, D Crosignani, P Tumino, R Panico, S Bueno-De-Mesquita, H Peeters, P Lund, E Gonzalez, C Martinez, C Dorronsoro, M |
| author_sort | Vineis, P |
| collection | OXFORD |
| description | Background: We chose a set of candidate single nucleotide polymorphisms (SNPs) to investigate gene-environment interactions in three types of cancer that have been related to air pollution (lung, bladder and myeloid leukemia). Patients and methods: The study has been conducted as a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (409 cancer cases and 757 matched controls). We included never and ex-smokers. SNPs were in genes involved in oxidative stress, phase I metabolizing genes, phase II metabolizing genes and methylenetetrahydrofolate reductase (MTHFR). Results: The most notable findings are: GSTM1 deletion and bladder cancer risk [odds ratio (OR) = 1.60; 95% confidence interval 1.00-2.56]; CYP1A1 and leukemia (2.22, 1.33-3.70; heterozygotes); CYP1B1 and leukemia (0.47, 0.27-0.84; homozygotes); MnSOD and leukemia (1.91, 1.08-3.38; homozygotes) and NQO1 and lung cancer (8.03, 1.73-37.3; homozygotes). Other statistically significant associations were found in subgroups defined by smoking habits (never or ex-smokers), environmental tobacco smoke or gender, with no obvious pattern. When gene variants were organized according to the three main pathways, the emerging picture was of a strong involvement of combined phase I enzymes in leukemia, with an OR of 5 (1.63-15.4) for those having three or more variant alleles. The association was considerably stronger for leukemias arising before the age of 55. © 2007 European Society for Medical Oncology. |
| first_indexed | 2024-03-06T22:56:44Z |
| format | Journal article |
| id | oxford-uuid:60a81884-1ba2-49bd-9efd-d11a6604e210 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:56:44Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:60a81884-1ba2-49bd-9efd-d11a6604e2102022-03-26T17:54:41ZGenetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokersJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:60a81884-1ba2-49bd-9efd-d11a6604e210EnglishSymplectic Elements at Oxford2007Vineis, PVeglia, FGarte, SMalaveille, CMatullo, GDunning, APeluso, MAiroldi, LOvervad, KRaaschou-Nielsen, OClavel-Chapelon, FLinseisen, JKaaks, RBoeing, HTrichopoulou, APalli, DCrosignani, PTumino, RPanico, SBueno-De-Mesquita, HPeeters, PLund, EGonzalez, CMartinez, CDorronsoro, MBackground: We chose a set of candidate single nucleotide polymorphisms (SNPs) to investigate gene-environment interactions in three types of cancer that have been related to air pollution (lung, bladder and myeloid leukemia). Patients and methods: The study has been conducted as a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (409 cancer cases and 757 matched controls). We included never and ex-smokers. SNPs were in genes involved in oxidative stress, phase I metabolizing genes, phase II metabolizing genes and methylenetetrahydrofolate reductase (MTHFR). Results: The most notable findings are: GSTM1 deletion and bladder cancer risk [odds ratio (OR) = 1.60; 95% confidence interval 1.00-2.56]; CYP1A1 and leukemia (2.22, 1.33-3.70; heterozygotes); CYP1B1 and leukemia (0.47, 0.27-0.84; homozygotes); MnSOD and leukemia (1.91, 1.08-3.38; homozygotes) and NQO1 and lung cancer (8.03, 1.73-37.3; homozygotes). Other statistically significant associations were found in subgroups defined by smoking habits (never or ex-smokers), environmental tobacco smoke or gender, with no obvious pattern. When gene variants were organized according to the three main pathways, the emerging picture was of a strong involvement of combined phase I enzymes in leukemia, with an OR of 5 (1.63-15.4) for those having three or more variant alleles. The association was considerably stronger for leukemias arising before the age of 55. © 2007 European Society for Medical Oncology. |
| spellingShingle | Vineis, P Veglia, F Garte, S Malaveille, C Matullo, G Dunning, A Peluso, M Airoldi, L Overvad, K Raaschou-Nielsen, O Clavel-Chapelon, F Linseisen, J Kaaks, R Boeing, H Trichopoulou, A Palli, D Crosignani, P Tumino, R Panico, S Bueno-De-Mesquita, H Peeters, P Lund, E Gonzalez, C Martinez, C Dorronsoro, M Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers |
| title | Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers |
| title_full | Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers |
| title_fullStr | Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers |
| title_full_unstemmed | Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers |
| title_short | Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers |
| title_sort | genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers |
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