SARS-CoV-2 mutations affect antigen processing by the proteasome to alter CD8+ T cell responses

Mutations within viral epitopes can result in escape from T cells, but the contribution of mutations in flanking regions of epitopes in SARS-CoV-2 has not been investigated. Focusing on two SARS-CoV-2 nucleoprotein CD8+ epitopes, we investigated the contribution of these flanking mutations to protea...

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Bibliographic Details
Main Authors: Wellington, D, Yin, Z, Yu, Z, Heilig, R, Davis, S, Fischer, R, Felce, SL, Antoun, E, Hublitz, P, Beveridge, R, Dong, D, Liu, G, Yao, X, Peng, Y, Kessler, B, Dong, T
Format: Journal article
Language:English
Published: Elsevier 2023