Lessons for tuberculosis vaccines from respiratory virus infection.
There is a worldwide epidemic of increasingly drug-resistant TB. Bacillus Calmette-Guérin vaccination provides partial protection against disseminated disease in infants but poor protection against later pulmonary TB. Cell-mediated protection against respiratory virus infections requires the presenc...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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| _version_ | 1797071704187469824 |
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| author | Beverley, P Tchilian, E |
| author_facet | Beverley, P Tchilian, E |
| author_sort | Beverley, P |
| collection | OXFORD |
| description | There is a worldwide epidemic of increasingly drug-resistant TB. Bacillus Calmette-Guérin vaccination provides partial protection against disseminated disease in infants but poor protection against later pulmonary TB. Cell-mediated protection against respiratory virus infections requires the presence of T cells in lung tissues, and the most effective prime-boost immunizations for Mycobacterium tuberculosis also induce lung-resident lymphocytes. These observations need to be taken into account when designing future vaccines against M. tuberculosis. |
| first_indexed | 2024-03-06T22:57:09Z |
| format | Journal article |
| id | oxford-uuid:60cffaa9-b0e6-4826-abe6-e1105204e7ba |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:57:09Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:60cffaa9-b0e6-4826-abe6-e1105204e7ba2022-03-26T17:55:36ZLessons for tuberculosis vaccines from respiratory virus infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:60cffaa9-b0e6-4826-abe6-e1105204e7baEnglishSymplectic Elements at Oxford2008Beverley, PTchilian, EThere is a worldwide epidemic of increasingly drug-resistant TB. Bacillus Calmette-Guérin vaccination provides partial protection against disseminated disease in infants but poor protection against later pulmonary TB. Cell-mediated protection against respiratory virus infections requires the presence of T cells in lung tissues, and the most effective prime-boost immunizations for Mycobacterium tuberculosis also induce lung-resident lymphocytes. These observations need to be taken into account when designing future vaccines against M. tuberculosis. |
| spellingShingle | Beverley, P Tchilian, E Lessons for tuberculosis vaccines from respiratory virus infection. |
| title | Lessons for tuberculosis vaccines from respiratory virus infection. |
| title_full | Lessons for tuberculosis vaccines from respiratory virus infection. |
| title_fullStr | Lessons for tuberculosis vaccines from respiratory virus infection. |
| title_full_unstemmed | Lessons for tuberculosis vaccines from respiratory virus infection. |
| title_short | Lessons for tuberculosis vaccines from respiratory virus infection. |
| title_sort | lessons for tuberculosis vaccines from respiratory virus infection |
| work_keys_str_mv | AT beverleyp lessonsfortuberculosisvaccinesfromrespiratoryvirusinfection AT tchiliane lessonsfortuberculosisvaccinesfromrespiratoryvirusinfection |