Keeping IGF-II under control: lessons from the IGF-II-IGF2R crystal structure.
Insulin-like growth factor-II (IGF-II) is a key regulator of cell growth, survival, migration and differentiation. Its pivotal role in these processes requires tight regulation of both expression and activity. The type 1 IGF receptor tyrosine kinase (IGF-1R) mediates IGF-II actions, and a family of...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2009
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| _version_ | 1826275341819183104 |
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| author | Brown, J Jones, E Forbes, B |
| author_facet | Brown, J Jones, E Forbes, B |
| author_sort | Brown, J |
| collection | OXFORD |
| description | Insulin-like growth factor-II (IGF-II) is a key regulator of cell growth, survival, migration and differentiation. Its pivotal role in these processes requires tight regulation of both expression and activity. The type 1 IGF receptor tyrosine kinase (IGF-1R) mediates IGF-II actions, and a family of six high affinity IGF binding proteins (IGFBPs) regulates IGF-II circulating half-life and its availability to bind IGF-1R. In addition, the type 2 IGF receptor (IGF2R; also called the cation-independent mannose-6-phosphate receptor) modulates the circulating and tissue levels of IGF-II by targeting it to lysosomes for degradation. The recently elucidated crystal structure of IGF-II-IGF2R complex provides new insight into IGF-II regulation, and reveals a common binding surface on IGF-II for the regulatory proteins, IGF2R and the IGFBPs. |
| first_indexed | 2024-03-06T22:57:15Z |
| format | Journal article |
| id | oxford-uuid:60da56ae-f6a1-47a3-a832-24b22e12a3ee |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:57:15Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:60da56ae-f6a1-47a3-a832-24b22e12a3ee2022-03-26T17:55:50ZKeeping IGF-II under control: lessons from the IGF-II-IGF2R crystal structure.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:60da56ae-f6a1-47a3-a832-24b22e12a3eeEnglishSymplectic Elements at Oxford2009Brown, JJones, EForbes, BInsulin-like growth factor-II (IGF-II) is a key regulator of cell growth, survival, migration and differentiation. Its pivotal role in these processes requires tight regulation of both expression and activity. The type 1 IGF receptor tyrosine kinase (IGF-1R) mediates IGF-II actions, and a family of six high affinity IGF binding proteins (IGFBPs) regulates IGF-II circulating half-life and its availability to bind IGF-1R. In addition, the type 2 IGF receptor (IGF2R; also called the cation-independent mannose-6-phosphate receptor) modulates the circulating and tissue levels of IGF-II by targeting it to lysosomes for degradation. The recently elucidated crystal structure of IGF-II-IGF2R complex provides new insight into IGF-II regulation, and reveals a common binding surface on IGF-II for the regulatory proteins, IGF2R and the IGFBPs. |
| spellingShingle | Brown, J Jones, E Forbes, B Keeping IGF-II under control: lessons from the IGF-II-IGF2R crystal structure. |
| title | Keeping IGF-II under control: lessons from the IGF-II-IGF2R crystal structure. |
| title_full | Keeping IGF-II under control: lessons from the IGF-II-IGF2R crystal structure. |
| title_fullStr | Keeping IGF-II under control: lessons from the IGF-II-IGF2R crystal structure. |
| title_full_unstemmed | Keeping IGF-II under control: lessons from the IGF-II-IGF2R crystal structure. |
| title_short | Keeping IGF-II under control: lessons from the IGF-II-IGF2R crystal structure. |
| title_sort | keeping igf ii under control lessons from the igf ii igf2r crystal structure |
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