Keeping IGF-II under control: lessons from the IGF-II-IGF2R crystal structure.
Insulin-like growth factor-II (IGF-II) is a key regulator of cell growth, survival, migration and differentiation. Its pivotal role in these processes requires tight regulation of both expression and activity. The type 1 IGF receptor tyrosine kinase (IGF-1R) mediates IGF-II actions, and a family of...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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