Keeping IGF-II under control: lessons from the IGF-II-IGF2R crystal structure.

Keeping IGF-II under control: lessons from the IGF-II-IGF2R crystal structure.

Insulin-like growth factor-II (IGF-II) is a key regulator of cell growth, survival, migration and differentiation. Its pivotal role in these processes requires tight regulation of both expression and activity. The type 1 IGF receptor tyrosine kinase (IGF-1R) mediates IGF-II actions, and a family of...

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Bibliographic Details
Main Authors:	Brown, J, Jones, E, Forbes, B
Format:	Journal article
Language:	English
Published:	2009

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