Health-related quality of life in patients with newly diagnosed antineutrophil cytoplasmic antibody-associated vasculitis.
OBJECTIVE: Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) can present with a broad spectrum of signs and symptoms. The relative effects of different manifestations on health-related quality of life (HRQOL) are unknown. METHODS: We conducted an individual patient data meta-analysis o...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1797071714509651968 |
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| author | Walsh, M Mukhtyar, C Mahr, A Herlyn, K Luqmani, R Merkel, P Jayne, DR |
| author_facet | Walsh, M Mukhtyar, C Mahr, A Herlyn, K Luqmani, R Merkel, P Jayne, DR |
| author_sort | Walsh, M |
| collection | OXFORD |
| description | OBJECTIVE: Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) can present with a broad spectrum of signs and symptoms. The relative effects of different manifestations on health-related quality of life (HRQOL) are unknown. METHODS: We conducted an individual patient data meta-analysis of baseline Short Form 36 (SF-36) scores from 4 randomized controlled trials of patients with newly diagnosed AAV. We determined the associations between organ manifestations at trial entry and the SF-36 physical composite score (PCS) and mental composite score (MCS) using mixed-effects models adjusted for demographic factors. Associations with each of the 8 domains of the SF-36 were further explored using multivariate multiple regression. RESULTS: SF-36 data were available from 346 patients. Older age (-0.11 points/year [95% confidence interval (95% CI) -0.21, -0.012]; P = 0.029) and neurologic involvement (-5.84 points; P < 0.001) at baseline were associated with lower PCS. Physical functioning scores were the most affected and older age scores (-0.25 points/year [95% CI -0.38, -0.11]; P < 0.001) and neurologic involvement (-8.48 points [95% CI -12.90, -4.06]; P < 0.001) had the largest effects. The MCS was negatively affected only by chest involvement (P = 0.027), but this effect was not exerted in any particular domain. CONCLUSION: In patients with newly diagnosed AAV, HRQOL is complex and incompletely explained by their organ system manifestations. |
| first_indexed | 2024-03-06T22:57:19Z |
| format | Journal article |
| id | oxford-uuid:60e09632-d4d8-4ffd-b458-01db4285ffdd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:57:19Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:60e09632-d4d8-4ffd-b458-01db4285ffdd2022-03-26T17:55:57ZHealth-related quality of life in patients with newly diagnosed antineutrophil cytoplasmic antibody-associated vasculitis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:60e09632-d4d8-4ffd-b458-01db4285ffddEnglishSymplectic Elements at Oxford2011Walsh, MMukhtyar, CMahr, AHerlyn, KLuqmani, RMerkel, PJayne, DROBJECTIVE: Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) can present with a broad spectrum of signs and symptoms. The relative effects of different manifestations on health-related quality of life (HRQOL) are unknown. METHODS: We conducted an individual patient data meta-analysis of baseline Short Form 36 (SF-36) scores from 4 randomized controlled trials of patients with newly diagnosed AAV. We determined the associations between organ manifestations at trial entry and the SF-36 physical composite score (PCS) and mental composite score (MCS) using mixed-effects models adjusted for demographic factors. Associations with each of the 8 domains of the SF-36 were further explored using multivariate multiple regression. RESULTS: SF-36 data were available from 346 patients. Older age (-0.11 points/year [95% confidence interval (95% CI) -0.21, -0.012]; P = 0.029) and neurologic involvement (-5.84 points; P < 0.001) at baseline were associated with lower PCS. Physical functioning scores were the most affected and older age scores (-0.25 points/year [95% CI -0.38, -0.11]; P < 0.001) and neurologic involvement (-8.48 points [95% CI -12.90, -4.06]; P < 0.001) had the largest effects. The MCS was negatively affected only by chest involvement (P = 0.027), but this effect was not exerted in any particular domain. CONCLUSION: In patients with newly diagnosed AAV, HRQOL is complex and incompletely explained by their organ system manifestations. |
| spellingShingle | Walsh, M Mukhtyar, C Mahr, A Herlyn, K Luqmani, R Merkel, P Jayne, DR Health-related quality of life in patients with newly diagnosed antineutrophil cytoplasmic antibody-associated vasculitis. |
| title | Health-related quality of life in patients with newly diagnosed antineutrophil cytoplasmic antibody-associated vasculitis. |
| title_full | Health-related quality of life in patients with newly diagnosed antineutrophil cytoplasmic antibody-associated vasculitis. |
| title_fullStr | Health-related quality of life in patients with newly diagnosed antineutrophil cytoplasmic antibody-associated vasculitis. |
| title_full_unstemmed | Health-related quality of life in patients with newly diagnosed antineutrophil cytoplasmic antibody-associated vasculitis. |
| title_short | Health-related quality of life in patients with newly diagnosed antineutrophil cytoplasmic antibody-associated vasculitis. |
| title_sort | health related quality of life in patients with newly diagnosed antineutrophil cytoplasmic antibody associated vasculitis |
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