Ahaptoglobinaemia in Melanesia: DNA and malarial antibody studies.

Ahaptoglobinaemia in Melanesia: DNA and malarial antibody studies.

To assess the relative contributions of genetic and acquired factors, particularly malaria, to the high frequencies of ahaptoglobinaemia found in Melanesia we have performed DNA and malarial antibody studies in a population from Vanuatu. No gene deletion or rearrangement was found on gene mapping in...

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Dades bibliogràfiques
Autors principals: Hill, A, Whitehouse, D, Bowden, D, Hopkinson, D, Draper, C, Peto, T, Clegg, J, Weatherall, D
Format: Journal article
Idioma:English
Publicat: 1987
Descripció
Sumari:To assess the relative contributions of genetic and acquired factors, particularly malaria, to the high frequencies of ahaptoglobinaemia found in Melanesia we have performed DNA and malarial antibody studies in a population from Vanuatu. No gene deletion or rearrangement was found on gene mapping in any ahaptoglobinaemic individual and the frequencies of the Hp1 and Hp2 alleles in the ahaptoglobinaemic group were similar to controls. However, antibodies to Plasmodium falciparum were significantly elevated in the ahaptoglobinaemics. These data suggest that malaria rather than genetic factors is the major cause of ahaptoglobinaemia in Melanesia.

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