Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses.
Lipid antigens trigger help from natural killer T cells (NKT cells) for B cells, and direct conjugation of lipid agonists to antigen profoundly augments antibody responses. Here we show that in vivo, NKT cells engaged in stable and prolonged cognate interactions with B cells and induced the formatio...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1797071760318791680 |
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| author | Chang, P Barral, P Fitch, J Pratama, A Ma, C Kallies, A Hogan, J Cerundolo, V Tangye, S Bittman, R Nutt, S Brink, R Godfrey, D Batista, F Vinuesa, C |
| author_facet | Chang, P Barral, P Fitch, J Pratama, A Ma, C Kallies, A Hogan, J Cerundolo, V Tangye, S Bittman, R Nutt, S Brink, R Godfrey, D Batista, F Vinuesa, C |
| author_sort | Chang, P |
| collection | OXFORD |
| description | Lipid antigens trigger help from natural killer T cells (NKT cells) for B cells, and direct conjugation of lipid agonists to antigen profoundly augments antibody responses. Here we show that in vivo, NKT cells engaged in stable and prolonged cognate interactions with B cells and induced the formation of early germinal centers. Mouse and human NKT cells formed CXCR5(+)PD-1(hi) follicular helper NKT cells (NKT(FH) cells), and this process required expression of the transcriptional repressor Bcl-6, signaling via the coreceptor CD28 and interaction with B cells. NKT(FH) cells provided direct cognate help to antigen-specific B cells that was dependent on interleukin 21 (IL-21). Unlike T cell-dependent germinal centers, those driven by NKT(FH) cells did not generate long-lived plasma cells. Our results demonstrate the existence of a Bcl-6-dependent subset of NKT cells specialized in providing help to B cells. |
| first_indexed | 2024-03-06T22:57:50Z |
| format | Journal article |
| id | oxford-uuid:610a99b5-102b-4c00-baf1-bf5f90338c00 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:57:50Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:610a99b5-102b-4c00-baf1-bf5f90338c002022-03-26T17:57:05ZIdentification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:610a99b5-102b-4c00-baf1-bf5f90338c00EnglishSymplectic Elements at Oxford2012Chang, PBarral, PFitch, JPratama, AMa, CKallies, AHogan, JCerundolo, VTangye, SBittman, RNutt, SBrink, RGodfrey, DBatista, FVinuesa, CLipid antigens trigger help from natural killer T cells (NKT cells) for B cells, and direct conjugation of lipid agonists to antigen profoundly augments antibody responses. Here we show that in vivo, NKT cells engaged in stable and prolonged cognate interactions with B cells and induced the formation of early germinal centers. Mouse and human NKT cells formed CXCR5(+)PD-1(hi) follicular helper NKT cells (NKT(FH) cells), and this process required expression of the transcriptional repressor Bcl-6, signaling via the coreceptor CD28 and interaction with B cells. NKT(FH) cells provided direct cognate help to antigen-specific B cells that was dependent on interleukin 21 (IL-21). Unlike T cell-dependent germinal centers, those driven by NKT(FH) cells did not generate long-lived plasma cells. Our results demonstrate the existence of a Bcl-6-dependent subset of NKT cells specialized in providing help to B cells. |
| spellingShingle | Chang, P Barral, P Fitch, J Pratama, A Ma, C Kallies, A Hogan, J Cerundolo, V Tangye, S Bittman, R Nutt, S Brink, R Godfrey, D Batista, F Vinuesa, C Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses. |
| title | Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses. |
| title_full | Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses. |
| title_fullStr | Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses. |
| title_full_unstemmed | Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses. |
| title_short | Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses. |
| title_sort | identification of bcl 6 dependent follicular helper nkt cells that provide cognate help for b cell responses |
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