Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial

Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial

<p><strong>Background</strong></p> Doxycycline is often used for treating COVID-19 respiratory symptoms in the community despite an absence of evidence from clinical trials to support its use. We aimed to assess the efficacy of doxycycline to treat suspected COVID-19 in the c...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Butler, CC, Yu, L-M, Dorward, J, Gbinigie, O, Hayward, G, Saville, BR, Van Hecke, O, Berry, N, Detry, MA, Saunders, C, Fitzgerald, M, Harris, V, Djukanovic, R, Gadola, S, Kirkpatrick, J, Ogburn, E, Patel, MG, de Lusignan, S, Evans, PH, Thomas, NPB, Hobbs, FDR
Бусад зохиолчид:	PRINCIPLE Trial Collaborative Group
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	Elsevier 2021

Ижил төстэй зүйлс

Azithromycin for community treatment of suspected COVID-19 in people at increased risk of an adverse clinical course in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial
-н: PRINCIPLE Trial Collaborative Group, зэрэг
Хэвлэсэн: (2021)

Inhaled budesonide for COVID-19 in people at higher risk of adverse outcomes in the community: interim analyses from the PRINCIPLE trial
-н: Yu, L-M, зэрэг
Хэвлэсэн: (2021)

Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial
-н: Yu, L-M, зэрэг
Хэвлэсэн: (2021)

Colchicine for COVID-19 in adults in the community (PRINCIPLE): a randomised, controlled, adaptive platform trial
-н: PRINCIPLE Trial Collaborative Group, зэрэг
Хэвлэсэн: (2021)

Colchicine for COVID-19 in the community (PRINCIPLE): a randomised, controlled, adaptive platform trial
-н: Dorward, J, зэрэг
Хэвлэсэн: (2022)

Inhaled budesonide for COVID-19 in people at higher risk of complications in the community: the UK National Community Randomi
-н: Gbinigie, O, зэрэг
Хэвлэсэн: (2023)

Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE): protocol for a randomised, controlled, open-label, adaptive platform, trial of community treatment of COVID-19 syndromic illness in people at higher risk
-н: Hayward, G, зэрэг
Хэвлэсэн: (2021)

Ivermectin for COVID-19 in adults in the community (PRINCIPLE): an open, randomised, controlled, adaptive platform trial of short- and longer-term outcomes
-н: Hayward, G, зэрэг
Хэвлэсэн: (2024)

High-dose budesonide for early COVID-19 - Authors' reply
-н: Hobbs, FDR, зэрэг
Хэвлэсэн: (2021)

PRINCIPLE trial demonstrates scope for in-pandemic improvement in primary care antibiotic stewardship
-н: de Lusignan, S, зэрэг
Хэвлэсэн: (2021)

The protease inhibitor lopinavir, boosted with ritonavir, as treatment for COVID-19: A rapid review
-н: Dorward, J, зэрэг
Хэвлэсэн: (2021)

Inclusion and diversity in the PRINCIPLE trial
-н: Patel, MG, зэрэг
Хэвлэсэн: (2021)

Suspected Doxycycline Induced Acute Interstitial Nephritis
-н: Andrew Abrahamian, зэрэг
Хэвлэсэн: (2023-05-01)

PRINCIPLE trial demonstrates scope for in-pandemic improvement in primary care antibiotic stewardship: a retrospective sentinel network cohort study.
-н: de Lusignan, S, зэрэг
Хэвлэсэн: (2021)

Doxycycline for the prevention of progression of COVID-19 to severe disease requiring intensive care unit (ICU) admission: A randomized, controlled, open-label, parallel group trial (DOXPREVENT.ICU).
-н: Raja Dhar, зэрэг
Хэвлэсэн: (2023-01-01)

Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial
-н: Butler, CC, зэрэг
Хэвлэсэн: (2022)

Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): preliminary analysis from the united kingdom randomised, controlled open-label, platform adaptive trial
-н: Butler, C, зэрэг
Хэвлэсэн: (2022)

A targeted approach to vaccine hesitancy
-н: Leston, M, зэрэг
Хэвлэсэн: (2023)

PRINCIPLE trial demonstrates scope for in-pandemic improvement in primary care antibiotic stewardship: a retrospective sentinel network cohort study
-н: Simon de Lusignan, зэрэг
Хэвлэсэн: (2021-10-01)

Penetration of doxycycline in aqueous humour
-н: Kulshrestha O, зэрэг
Хэвлэсэн: (1981-01-01)

Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE): protocol for a randomised, controlled, open-label, adaptive platform, trial of community treatment of COVID-19 syndromic illness in people at higher risk
-н: Sarah Tonkin-Crine, зэрэг
Хэвлэсэн: (2021-06-01)

Excess mortality from COVID-19 in an English sentinel network population
-н: Joy, M, зэрэг
Хэвлэсэн: (2020)

Doxycycline prophylaxis in malaria.
-н: Gilks, C, зэрэг
Хэвлэсэн: (1987)

Doxycycline induced Esophagitis
-н: Banu Karakus Yilmaz, зэрэг
Хэвлэсэн: (2014-02-01)

Comparison between Efficacy of Ciprofioxacin -Doxycycline with Rifampin – Doxycycline Regimens inrelapse of Brucellosis
-н: Hossein Sarmadian, зэрэг
Хэвлэсэн: (2014-08-01)

A comparison of chloramphenicol, trimethoprim-sulfamethoxazole, and doxycycline with doxycycline alone as maintenance therapy for melioidosis.
-н: Chaowagul, W, зэрэг
Хэвлэсэн: (1999)

Transdermal Delivery System of Doxycycline-Loaded Niosomal Gels: Toward Enhancing Doxycycline Stability
-н: Ahlam Zaid Alkilani, зэрэг
Хэвлэсэн: (2024-07-01)

Effect of doxycycline and doxycycline with carica papaya on thrombocytopenia and leucopenia in acute dengue fever patients
-н: Vivek Pambhar, зэрэг
Хэвлэсэн: (2022-01-01)

Different Concentrations of Doxycycline in Swine Manure Affect the Microbiome and Degradation of Doxycycline Residue in Soil
-н: Qiufan Yan, зэрэг
Хэвлэсэн: (2018-12-01)

Treatment of Morgellons disease with doxycycline
-н: Jeff F. Zhang, зэрэг
Хэвлэсэн: (2021-12-01)

Actinic granuloma responding to doxycycline
-н: George M. Jeha, BS, зэрэг
Хэвлэсэн: (2020-11-01)

Doxycycline in the current clinical practice
-н: Zyryanov S.K., зэрэг
Хэвлэсэн: (2020-03-01)

Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial of community novel antiviral treatment of COVID-19 in people at increased risk of more severe disease
-н: Gbinigie, O, зэрэг
Хэвлэсэн: (2023)

Evaluation of the doxycycline release from AH26 sealer-doxycycline combination: An ex vivo study
-н: Kazem Ashofteh Yazdi, зэрэг
Хэвлэсэн: (2011-09-01)

Doxycycline promotes proteasome fitness in the central nervous system
-н: Edmund Charles Jenkins, зэрэг
Хэвлэсэн: (2021-08-01)

Experiences of urine collection devices during suspected Urinary Tract Infections: qualitative study
-н: Glogowska, M, зэрэг
Хэвлэсэн: (2023)

Doxycycline PEP can induce doxycycline resistance in Klebsiella pneumoniae in a Galleria mellonella model of PEP
-н: Chris Kenyon, зэрэг
Хэвлэсэн: (2023-08-01)

Scrub typhus and the misconception of doxycycline resistance
-н: Wangrangsimakul, T, зэрэг
Хэвлэсэн: (2019)

Doxycycline Degradation by the Oxidative Fenton Process
-н: Alexandre A. Borghi, зэрэг
Хэвлэсэн: (2015-01-01)

Use of doxycycline in modern clinical practice
-н: R. S. Kozlov, зэрэг
Хэвлэсэн: (2014-12-01)