Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate.
Alpha-halogenated analogues of the anti-resorptive bisphosphonate risedronate (5, Ris) and its phosphonocarboxylate cognate (7, 3-PEHPC) were synthesized and compared with 5, 7, and the corresponding desoxy analogues in bone mineral affinity and mevalonate pathway inhibition assays. The Ris (5e-h) a...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1797071813255102464 |
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| author | Marma, MS Xia, Z Stewart, C Coxon, F Dunford, J Baron, R Kashemirov, B Ebetino, F Triffitt, J Russell, R McKenna, C |
| author_facet | Marma, MS Xia, Z Stewart, C Coxon, F Dunford, J Baron, R Kashemirov, B Ebetino, F Triffitt, J Russell, R McKenna, C |
| author_sort | Marma, MS |
| collection | OXFORD |
| description | Alpha-halogenated analogues of the anti-resorptive bisphosphonate risedronate (5, Ris) and its phosphonocarboxylate cognate (7, 3-PEHPC) were synthesized and compared with 5, 7, and the corresponding desoxy analogues in bone mineral affinity and mevalonate pathway inhibition assays. The Ris (5e-h) and 3-PEHPC (7e-h) analogues had decreased bone mineral affinity, confirming that the alpha-OH group in 5 and 7 enhances bone affinity. The 5 alpha-halo-analogues potently inhibited farnesyl pyrophosphate synthase (FPPS) with IC50 values from 16 (alpha-F) to 340 (alpha-Br) nM (5, 6 nM). In contrast, 7 alpha-halo-analogues were ineffective versus FPPS (IC50 > 600 microM), but inhibited Rab geranylgeranyl transferase (RGGT) (IC50 = 16-35 microM) similarly to 7 itself (IC50 = 24 microM). The alpha-F analogue 7e was 1-2 times as active as 7 in J774 cell viability and Rab11 prenylation inhibition assays. |
| first_indexed | 2024-03-06T22:58:38Z |
| format | Journal article |
| id | oxford-uuid:614c8fca-0223-4157-95d6-c40937a79081 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:58:38Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:614c8fca-0223-4157-95d6-c40937a790812022-03-26T17:58:57ZSynthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:614c8fca-0223-4157-95d6-c40937a79081EnglishSymplectic Elements at Oxford2007Marma, MSXia, ZStewart, CCoxon, FDunford, JBaron, RKashemirov, BEbetino, FTriffitt, JRussell, RMcKenna, CAlpha-halogenated analogues of the anti-resorptive bisphosphonate risedronate (5, Ris) and its phosphonocarboxylate cognate (7, 3-PEHPC) were synthesized and compared with 5, 7, and the corresponding desoxy analogues in bone mineral affinity and mevalonate pathway inhibition assays. The Ris (5e-h) and 3-PEHPC (7e-h) analogues had decreased bone mineral affinity, confirming that the alpha-OH group in 5 and 7 enhances bone affinity. The 5 alpha-halo-analogues potently inhibited farnesyl pyrophosphate synthase (FPPS) with IC50 values from 16 (alpha-F) to 340 (alpha-Br) nM (5, 6 nM). In contrast, 7 alpha-halo-analogues were ineffective versus FPPS (IC50 > 600 microM), but inhibited Rab geranylgeranyl transferase (RGGT) (IC50 = 16-35 microM) similarly to 7 itself (IC50 = 24 microM). The alpha-F analogue 7e was 1-2 times as active as 7 in J774 cell viability and Rab11 prenylation inhibition assays. |
| spellingShingle | Marma, MS Xia, Z Stewart, C Coxon, F Dunford, J Baron, R Kashemirov, B Ebetino, F Triffitt, J Russell, R McKenna, C Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. |
| title | Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. |
| title_full | Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. |
| title_fullStr | Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. |
| title_full_unstemmed | Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. |
| title_short | Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. |
| title_sort | synthesis and biological evaluation of alpha halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate |
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