X-ray studies on the mechanism of IPNS using substrate analogs
The substrate analog L-S-(a-aminoadipoyl)-L-cysteinyl-glycine (ACG) was co-crystallised with isopenicillin N synthase using the hanging-drop vapourdiffusion method in an anaerobic environment. ' X-ray crystallography revealed a different mode of binding for ACG compared to the natural substrate...
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| Hlavní autoři: |
Long, A,
Clifton, I,
Roach, P,
Schofield, C,
Baldwin, J,
Hajdu, J |
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| Médium: | Journal article
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| Jazyk: | English |
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| Vydáno: |
1997
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