X-ray studies on the mechanism of IPNS using substrate analogs

X-ray studies on the mechanism of IPNS using substrate analogs

The substrate analog L-S-(a-aminoadipoyl)-L-cysteinyl-glycine (ACG) was co-crystallised with isopenicillin N synthase using the hanging-drop vapourdiffusion method in an anaerobic environment. ' X-ray crystallography revealed a different mode of binding for ACG compared to the natural substrate...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Long, A, Clifton, I, Roach, P, Schofield, C, Baldwin, J, Hajdu, J
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	1997

Eitemau Tebyg

Anaerobic crystallisation of an isopenicillin N synthase.Fe(II).substrate complex demonstrated by X-ray studies.
gan: Roach, P, et al.
Cyhoeddwyd: (1996)

Crystallization and preliminary X-ray diffraction studies on recombinant isopenicillin N synthase from Aspergillus nidulans.
gan: Roach, P, et al.
Cyhoeddwyd: (1995)

Anaerobic crystallisation of an isopenicillin N synthase center dot Fe(II)center dot substrate complex demonstrated by X-ray studies
gan: Roach, P, et al.
Cyhoeddwyd: (1996)

Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.
gan: Roach, P, et al.
Cyhoeddwyd: (1997)

Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate.
gan: Long, A, et al.
Cyhoeddwyd: (2003)

SUBSTRATE-ANALOG STUDIES ON CLAVAMINIC ACID SYNTHASE
gan: Baldwin, J, et al.
Cyhoeddwyd: (1993)

Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine.
gan: Long, A, et al.
Cyhoeddwyd: (2005)

X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate.
gan: Wilmouth, R, et al.
Cyhoeddwyd: (2001)

The biological applications of IPN hydrogels
gan: Maria I. León-Campos, et al.
Cyhoeddwyd: (2024-08-01)

Reinforcement of Dextran Methacrylate-Based Hydrogel, Semi-IPN, and IPN with Multivalent Crosslinkers
gan: Luca Paoletti, et al.
Cyhoeddwyd: (2024-11-01)

Proteins of the penicillin biosynthesis pathway.
gan: Schofield, C, et al.
Cyhoeddwyd: (1997)

Crystallization and preliminary X-ray diffraction studies on a recombinant isopenicillin N synthase from Cephalosporium acremonium.
gan: Fujishima, Y, et al.
Cyhoeddwyd: (1994)

IPNs around the world : science and engineering /
gan: Kim, S. C., et al.
Cyhoeddwyd: (1997)

A SUBSTRATE-ANALOG STUDY ON CLAVAMINIC ACID SYNTHASE - POSSIBLE CLUES TO THE BIOSYNTHETIC ORIGIN OF PROCLAVAMIC ACID
gan: Baldwin, J, et al.
Cyhoeddwyd: (1993)

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.
gan: Roach, P, et al.
Cyhoeddwyd: (1995)

SYNTHESIS OF A BICYCLIC GAMMA-LACTAM DIPEPTIDE ANALOG
gan: Baldwin, J, et al.
Cyhoeddwyd: (1992)

SYNTHESIS OF A NOVEL BICYCLIC GAMMA-LACTAM ANALOG OF THE 1-OXAPENAMS
gan: Baldwin, J, et al.
Cyhoeddwyd: (1989)

Investigations into the post-translational modification and mechanism of isopenicillin N:acyl-CoA acyltransferase using electrospray mass spectrometry.
gan: Aplin, RT, et al.
Cyhoeddwyd: (1993)

Inter-penetrating Polymer Network(IPN) tissue expanders
gan: Zhu, Y
Cyhoeddwyd: (2015)

Natural polymers, biopolymers, biomaterials, and their composites, blends, and ipns /
gan: Thomas, Sabu
Cyhoeddwyd: (2012)

Usuarios de la biblioteca del CICIMAR-IPN en México desde un enfoque organizacional (Users of the CICIMAR-IPN library in Mexico from an organizational approach)
gan: Teresa de J. Barriga Ramírez, et al.
Cyhoeddwyd: (2014-04-01)

Usuarios de la biblioteca del CICIMAR-IPN en México desde un enfoque organizacional (Users of the CICIMAR-IPN library in Mexico from an organizational approach)
gan: Teresa de J. Barriga Ramírez, et al.
Cyhoeddwyd: (2014-04-01)

Usuarios de la biblioteca del CICIMAR-IPN en México desde un enfoque organizacional (Users of the CICIMAR-IPN library in Mexico from an organizational approach)
gan: Teresa de J. Barriga Ramírez, et al.
Cyhoeddwyd: (2014-04-01)

A GAMMA-LACTAM ANALOG OF PENEMS POSSESSING ANTIBACTERIAL ACTIVITY
gan: Baldwin, J, et al.
Cyhoeddwyd: (1986)

Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase. The role of arginine 258.
gan: Lee, H, et al.
Cyhoeddwyd: (2001)

GAMMA-LACTAM ANALOGS OF CARBAPENICILLANIC ACIDS
gan: Baldwin, J, et al.
Cyhoeddwyd: (1985)

GAMMA-LACTAM ANALOGS OF CARBAPENICILLANIC ACIDS
gan: Baldwin, J, et al.
Cyhoeddwyd: (1986)

Structural and mechanistic studies on anthocyanidin synthase catalysed oxidation of flavanone substrates: the effect of C-2 stereochemistry on product selectivity and mechanism.
gan: Welford, R, et al.
Cyhoeddwyd: (2005)

SYNTHESIS OF A BICYCLIC GAMMA-LACTAM DIPEPTIDE ANALOG
gan: Baldwin, J, et al.
Cyhoeddwyd: (1993)

X-ray structure of a serine protease acyl-enzyme complex at 0.95-A resolution.
gan: Katona, G, et al.
Cyhoeddwyd: (2002)

FEATURES OF SUBSTRATES FORMATION FOR X-RAY RADIATION SENSOR
gan: I. V. Gasenkova, et al.
Cyhoeddwyd: (2019-06-01)

IPN journal of research and practice in public sector accounting and management /
gan: Malaysia. Institut Perakaunan Negara. Jabatan Akauntan Negara, issuing body 543177
Cyhoeddwyd: (2012)

Novel Cellulose-sodium Polyacrylate Ipn Hydrogel for Biodiesel Dehydration
gan: Giovana Almenara, et al.
Cyhoeddwyd: (2024-06-01)

Physicochemical Interactions in Nanofunctionalized Alginate/GelMA IPN Hydrogels
gan: Rana Kadri, et al.
Cyhoeddwyd: (2021-08-01)

X-ray absorption spectroscopic studies of the iron(II) active site of clavaminic acid synthase.
gan: Baldwin, J, et al.
Cyhoeddwyd: (1997)

A GAMMA-LACTAM ANALOG OF THE PENEMS POSSESSING ANTIBACTERIAL ACTIVITY
gan: Baldwin, J, et al.
Cyhoeddwyd: (1989)

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
gan: Kamil Gotfryd, et al.
Cyhoeddwyd: (2020-02-01)

The X-Ray Binary KS 1731{260: Possible Analogy with Her X-1
gan: Vojtěch Šimon
Cyhoeddwyd: (2014-12-01)

Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase.
gan: Wilmouth, R, et al.
Cyhoeddwyd: (1997)

Novel X-Ray and Antinucleus Searches for Dark Matter
gan: Roach, Brandon Michael
Cyhoeddwyd: (2023)