X-ray studies on the mechanism of IPNS using substrate analogs

X-ray studies on the mechanism of IPNS using substrate analogs

The substrate analog L-S-(a-aminoadipoyl)-L-cysteinyl-glycine (ACG) was co-crystallised with isopenicillin N synthase using the hanging-drop vapourdiffusion method in an anaerobic environment. ' X-ray crystallography revealed a different mode of binding for ACG compared to the natural substrate...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Long, A, Clifton, I, Roach, P, Schofield, C, Baldwin, J, Hajdu, J
Natura:	Journal article
Lingua:	English
Pubblicazione:	1997

Documenti analoghi

Anaerobic crystallisation of an isopenicillin N synthase.Fe(II).substrate complex demonstrated by X-ray studies.
di: Roach, P, et al.
Pubblicazione: (1996)

Crystallization and preliminary X-ray diffraction studies on recombinant isopenicillin N synthase from Aspergillus nidulans.
di: Roach, P, et al.
Pubblicazione: (1995)

Anaerobic crystallisation of an isopenicillin N synthase center dot Fe(II)center dot substrate complex demonstrated by X-ray studies
di: Roach, P, et al.
Pubblicazione: (1996)

Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.
di: Roach, P, et al.
Pubblicazione: (1997)

Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate.
di: Long, A, et al.
Pubblicazione: (2003)

SUBSTRATE-ANALOG STUDIES ON CLAVAMINIC ACID SYNTHASE
di: Baldwin, J, et al.
Pubblicazione: (1993)

Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine.
di: Long, A, et al.
Pubblicazione: (2005)

X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate.
di: Wilmouth, R, et al.
Pubblicazione: (2001)

The biological applications of IPN hydrogels
di: Maria I. León-Campos, et al.
Pubblicazione: (2024-08-01)

Reinforcement of Dextran Methacrylate-Based Hydrogel, Semi-IPN, and IPN with Multivalent Crosslinkers
di: Luca Paoletti, et al.
Pubblicazione: (2024-11-01)

Proteins of the penicillin biosynthesis pathway.
di: Schofield, C, et al.
Pubblicazione: (1997)

Crystallization and preliminary X-ray diffraction studies on a recombinant isopenicillin N synthase from Cephalosporium acremonium.
di: Fujishima, Y, et al.
Pubblicazione: (1994)

IPNs around the world : science and engineering /
di: Kim, S. C., et al.
Pubblicazione: (1997)

A SUBSTRATE-ANALOG STUDY ON CLAVAMINIC ACID SYNTHASE - POSSIBLE CLUES TO THE BIOSYNTHETIC ORIGIN OF PROCLAVAMIC ACID
di: Baldwin, J, et al.
Pubblicazione: (1993)

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.
di: Roach, P, et al.
Pubblicazione: (1995)

SYNTHESIS OF A BICYCLIC GAMMA-LACTAM DIPEPTIDE ANALOG
di: Baldwin, J, et al.
Pubblicazione: (1992)

SYNTHESIS OF A NOVEL BICYCLIC GAMMA-LACTAM ANALOG OF THE 1-OXAPENAMS
di: Baldwin, J, et al.
Pubblicazione: (1989)

Investigations into the post-translational modification and mechanism of isopenicillin N:acyl-CoA acyltransferase using electrospray mass spectrometry.
di: Aplin, RT, et al.
Pubblicazione: (1993)

Inter-penetrating Polymer Network(IPN) tissue expanders
di: Zhu, Y
Pubblicazione: (2015)

Natural polymers, biopolymers, biomaterials, and their composites, blends, and ipns /
di: Thomas, Sabu
Pubblicazione: (2012)

Usuarios de la biblioteca del CICIMAR-IPN en México desde un enfoque organizacional (Users of the CICIMAR-IPN library in Mexico from an organizational approach)
di: Teresa de J. Barriga Ramírez, et al.
Pubblicazione: (2014-04-01)

Usuarios de la biblioteca del CICIMAR-IPN en México desde un enfoque organizacional (Users of the CICIMAR-IPN library in Mexico from an organizational approach)
di: Teresa de J. Barriga Ramírez, et al.
Pubblicazione: (2014-04-01)

Usuarios de la biblioteca del CICIMAR-IPN en México desde un enfoque organizacional (Users of the CICIMAR-IPN library in Mexico from an organizational approach)
di: Teresa de J. Barriga Ramírez, et al.
Pubblicazione: (2014-04-01)

A GAMMA-LACTAM ANALOG OF PENEMS POSSESSING ANTIBACTERIAL ACTIVITY
di: Baldwin, J, et al.
Pubblicazione: (1986)

Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase. The role of arginine 258.
di: Lee, H, et al.
Pubblicazione: (2001)

GAMMA-LACTAM ANALOGS OF CARBAPENICILLANIC ACIDS
di: Baldwin, J, et al.
Pubblicazione: (1985)

GAMMA-LACTAM ANALOGS OF CARBAPENICILLANIC ACIDS
di: Baldwin, J, et al.
Pubblicazione: (1986)

Structural and mechanistic studies on anthocyanidin synthase catalysed oxidation of flavanone substrates: the effect of C-2 stereochemistry on product selectivity and mechanism.
di: Welford, R, et al.
Pubblicazione: (2005)

SYNTHESIS OF A BICYCLIC GAMMA-LACTAM DIPEPTIDE ANALOG
di: Baldwin, J, et al.
Pubblicazione: (1993)

X-ray structure of a serine protease acyl-enzyme complex at 0.95-A resolution.
di: Katona, G, et al.
Pubblicazione: (2002)

FEATURES OF SUBSTRATES FORMATION FOR X-RAY RADIATION SENSOR
di: I. V. Gasenkova, et al.
Pubblicazione: (2019-06-01)

IPN journal of research and practice in public sector accounting and management /
di: Malaysia. Institut Perakaunan Negara. Jabatan Akauntan Negara, issuing body 543177
Pubblicazione: (2012)

Novel Cellulose-sodium Polyacrylate Ipn Hydrogel for Biodiesel Dehydration
di: Giovana Almenara, et al.
Pubblicazione: (2024-06-01)

Physicochemical Interactions in Nanofunctionalized Alginate/GelMA IPN Hydrogels
di: Rana Kadri, et al.
Pubblicazione: (2021-08-01)

X-ray absorption spectroscopic studies of the iron(II) active site of clavaminic acid synthase.
di: Baldwin, J, et al.
Pubblicazione: (1997)

A GAMMA-LACTAM ANALOG OF THE PENEMS POSSESSING ANTIBACTERIAL ACTIVITY
di: Baldwin, J, et al.
Pubblicazione: (1989)

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
di: Kamil Gotfryd, et al.
Pubblicazione: (2020-02-01)

The X-Ray Binary KS 1731{260: Possible Analogy with Her X-1
di: Vojtěch Šimon
Pubblicazione: (2014-12-01)

Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase.
di: Wilmouth, R, et al.
Pubblicazione: (1997)

Novel X-Ray and Antinucleus Searches for Dark Matter
di: Roach, Brandon Michael
Pubblicazione: (2023)