Host-associated genetic import in Campylobacter jejuni.
Host association of Campylobacter jejuni was analyzed by using multilocus sequence typing data for 713 isolates from chickens and bovids (cattle and sheep). Commonly used summary measures of genotypes (sequence type and clonal complex) showed poor accuracy, but a method using the full allelic profil...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2007
|
| _version_ | 1797071827833454592 |
|---|---|
| author | McCarthy, N Colles, F Dingle, K Bagnall, M Manning, G Maiden, M Falush, D |
| author_facet | McCarthy, N Colles, F Dingle, K Bagnall, M Manning, G Maiden, M Falush, D |
| author_sort | McCarthy, N |
| collection | OXFORD |
| description | Host association of Campylobacter jejuni was analyzed by using multilocus sequence typing data for 713 isolates from chickens and bovids (cattle and sheep). Commonly used summary measures of genotypes (sequence type and clonal complex) showed poor accuracy, but a method using the full allelic profile showed 80% accuracy in distinguishing isolates from these 2 host groups. We explored the biologic basis of more accurate results with allelic profiles. Strains isolated from specific hosts have imported a substantial number of alleles while circulating in those host species. These results imply that 1) although Campylobacter moves frequently between hosts, most transmission is within species, and 2) lineages can acquire a host signature and potentially adapt to the host through recombination. Assignment using this signature enables improved prediction of source for pathogens that undergo frequent genetic recombination. |
| first_indexed | 2024-03-06T22:58:51Z |
| format | Journal article |
| id | oxford-uuid:615efb36-1b31-47a0-acd4-6c468fb54251 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:58:51Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:615efb36-1b31-47a0-acd4-6c468fb542512022-03-26T17:59:24ZHost-associated genetic import in Campylobacter jejuni.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:615efb36-1b31-47a0-acd4-6c468fb54251EnglishSymplectic Elements at Oxford2007McCarthy, NColles, FDingle, KBagnall, MManning, GMaiden, MFalush, DHost association of Campylobacter jejuni was analyzed by using multilocus sequence typing data for 713 isolates from chickens and bovids (cattle and sheep). Commonly used summary measures of genotypes (sequence type and clonal complex) showed poor accuracy, but a method using the full allelic profile showed 80% accuracy in distinguishing isolates from these 2 host groups. We explored the biologic basis of more accurate results with allelic profiles. Strains isolated from specific hosts have imported a substantial number of alleles while circulating in those host species. These results imply that 1) although Campylobacter moves frequently between hosts, most transmission is within species, and 2) lineages can acquire a host signature and potentially adapt to the host through recombination. Assignment using this signature enables improved prediction of source for pathogens that undergo frequent genetic recombination. |
| spellingShingle | McCarthy, N Colles, F Dingle, K Bagnall, M Manning, G Maiden, M Falush, D Host-associated genetic import in Campylobacter jejuni. |
| title | Host-associated genetic import in Campylobacter jejuni. |
| title_full | Host-associated genetic import in Campylobacter jejuni. |
| title_fullStr | Host-associated genetic import in Campylobacter jejuni. |
| title_full_unstemmed | Host-associated genetic import in Campylobacter jejuni. |
| title_short | Host-associated genetic import in Campylobacter jejuni. |
| title_sort | host associated genetic import in campylobacter jejuni |
| work_keys_str_mv | AT mccarthyn hostassociatedgeneticimportincampylobacterjejuni AT collesf hostassociatedgeneticimportincampylobacterjejuni AT dinglek hostassociatedgeneticimportincampylobacterjejuni AT bagnallm hostassociatedgeneticimportincampylobacterjejuni AT manningg hostassociatedgeneticimportincampylobacterjejuni AT maidenm hostassociatedgeneticimportincampylobacterjejuni AT falushd hostassociatedgeneticimportincampylobacterjejuni |