Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in Drosophila.
Dopaminergic neurons provide reward learning signals in mammals and insects. Recent work in Drosophila has demonstrated that water-reinforcing dopaminergic neurons are different to those for nutritious sugars. Here, we tested whether the sweet taste and nutrient properties of sugar reinforcement fu...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Cell Press
2015
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| _version_ | 1797071834288488448 |
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| author | Huetteroth, W Perisse, E Lin, S Klappenbach, M Burke, C Waddell, S |
| author_facet | Huetteroth, W Perisse, E Lin, S Klappenbach, M Burke, C Waddell, S |
| author_sort | Huetteroth, W |
| collection | OXFORD |
| description | Dopaminergic neurons provide reward learning signals in mammals and insects. Recent work in Drosophila has demonstrated that water-reinforcing dopaminergic neurons are different to those for nutritious sugars. Here, we tested whether the sweet taste and nutrient properties of sugar reinforcement further subdivide the fly reward system. We found that dopaminergic neurons expressing the OAMB octopamine receptor specifically convey the short-term reinforcing effects of sweet taste. These dopaminergic neurons project to the β'<sub>2</sub> and γ<sub>4</sub> regions of the mushroom body lobes. In contrast, nutrient-dependent long-term memory requires different dopaminergic neurons that project to the γ<sub>5b</sub> regions, and it can be artificially reinforced by those projecting to the β lobe and adjacent α<sub>1</sub> region. Surprisingly, whereas artificial implantation and expression of short-term memory occur in satiated flies, formation and expression of artificial long-term memory require flies to be hungry. These studies suggest that short-term and long-term sugar memories have different physiological constraints. They also demonstrate further functional heterogeneity within the rewarding dopaminergic neuron population. |
| first_indexed | 2024-03-06T22:58:57Z |
| format | Journal article |
| id | oxford-uuid:6167b626-32b0-4eca-ac1a-180b09c9b092 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:58:57Z |
| publishDate | 2015 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:6167b626-32b0-4eca-ac1a-180b09c9b0922022-03-26T17:59:43ZSweet taste and nutrient value subdivide rewarding dopaminergic neurons in Drosophila.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6167b626-32b0-4eca-ac1a-180b09c9b092EnglishSymplectic Elements at OxfordCell Press2015Huetteroth, WPerisse, ELin, SKlappenbach, MBurke, CWaddell, S Dopaminergic neurons provide reward learning signals in mammals and insects. Recent work in Drosophila has demonstrated that water-reinforcing dopaminergic neurons are different to those for nutritious sugars. Here, we tested whether the sweet taste and nutrient properties of sugar reinforcement further subdivide the fly reward system. We found that dopaminergic neurons expressing the OAMB octopamine receptor specifically convey the short-term reinforcing effects of sweet taste. These dopaminergic neurons project to the β'<sub>2</sub> and γ<sub>4</sub> regions of the mushroom body lobes. In contrast, nutrient-dependent long-term memory requires different dopaminergic neurons that project to the γ<sub>5b</sub> regions, and it can be artificially reinforced by those projecting to the β lobe and adjacent α<sub>1</sub> region. Surprisingly, whereas artificial implantation and expression of short-term memory occur in satiated flies, formation and expression of artificial long-term memory require flies to be hungry. These studies suggest that short-term and long-term sugar memories have different physiological constraints. They also demonstrate further functional heterogeneity within the rewarding dopaminergic neuron population. |
| spellingShingle | Huetteroth, W Perisse, E Lin, S Klappenbach, M Burke, C Waddell, S Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in Drosophila. |
| title | Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in Drosophila. |
| title_full | Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in Drosophila. |
| title_fullStr | Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in Drosophila. |
| title_full_unstemmed | Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in Drosophila. |
| title_short | Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in Drosophila. |
| title_sort | sweet taste and nutrient value subdivide rewarding dopaminergic neurons in drosophila |
| work_keys_str_mv | AT huetterothw sweettasteandnutrientvaluesubdividerewardingdopaminergicneuronsindrosophila AT perissee sweettasteandnutrientvaluesubdividerewardingdopaminergicneuronsindrosophila AT lins sweettasteandnutrientvaluesubdividerewardingdopaminergicneuronsindrosophila AT klappenbachm sweettasteandnutrientvaluesubdividerewardingdopaminergicneuronsindrosophila AT burkec sweettasteandnutrientvaluesubdividerewardingdopaminergicneuronsindrosophila AT waddells sweettasteandnutrientvaluesubdividerewardingdopaminergicneuronsindrosophila |