European lactase persistence genotype shows evidence of association with increase in body mass index.
The global prevalence of obesity has increased significantly in recent decades, mainly due to excess calorie intake and increasingly sedentary lifestyle. Here, we test the association between obesity measured by body mass index (BMI) and one of the best-known genetic variants showing strong selectiv...
| Huvudupphovsmän: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
2010
|
| _version_ | 1826275488880918528 |
|---|---|
| author | Kettunen, J Silander, K Saarela, O Amin, N Müller, M Timpson, N Surakka, I Ripatti, S Laitinen, J Hartikainen, A Pouta, A Lahermo, P Anttila, V Männistö, S Jula, A Virtamo, J Salomaa, V Lehtimäki, T Raitakari, O Gieger, C Wichmann, E Van Duijn, C Smith, G McCarthy, M Järvelin, MR |
| author_facet | Kettunen, J Silander, K Saarela, O Amin, N Müller, M Timpson, N Surakka, I Ripatti, S Laitinen, J Hartikainen, A Pouta, A Lahermo, P Anttila, V Männistö, S Jula, A Virtamo, J Salomaa, V Lehtimäki, T Raitakari, O Gieger, C Wichmann, E Van Duijn, C Smith, G McCarthy, M Järvelin, MR |
| author_sort | Kettunen, J |
| collection | OXFORD |
| description | The global prevalence of obesity has increased significantly in recent decades, mainly due to excess calorie intake and increasingly sedentary lifestyle. Here, we test the association between obesity measured by body mass index (BMI) and one of the best-known genetic variants showing strong selective pressure: the functional variant in the cis-regulatory element of the lactase gene. We tested this variant since it is presumed to provide nutritional advantage in specific physical and cultural environments. We genetically defined lactase persistence (LP) in 31 720 individuals from eight European population-based studies and one family study by genotyping or imputing the European LP variant (rs4988235). We performed a meta-analysis by pooling the beta-coefficient estimates of the relationship between rs4988235 and BMI from the nine studies and found that the carriers of the allele responsible for LP among Europeans showed higher BMI (P = 7.9 x 10(-5)). Since this locus has been shown to be prone to population stratification, we paid special attention to reveal any population substructure which might be responsible for the association signal. The best evidence of exclusion of stratification came from the Dutch family sample which is robust for stratification. In this study, we highlight issues in model selection in the genome-wide association studies and problems in imputation of these special genomic regions. |
| first_indexed | 2024-03-06T22:59:28Z |
| format | Journal article |
| id | oxford-uuid:61952c80-a058-45eb-932c-d109a018daf2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:59:28Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:61952c80-a058-45eb-932c-d109a018daf22022-03-26T18:01:02ZEuropean lactase persistence genotype shows evidence of association with increase in body mass index.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:61952c80-a058-45eb-932c-d109a018daf2EnglishSymplectic Elements at Oxford2010Kettunen, JSilander, KSaarela, OAmin, NMüller, MTimpson, NSurakka, IRipatti, SLaitinen, JHartikainen, APouta, ALahermo, PAnttila, VMännistö, SJula, AVirtamo, JSalomaa, VLehtimäki, TRaitakari, OGieger, CWichmann, EVan Duijn, CSmith, GMcCarthy, MJärvelin, MRThe global prevalence of obesity has increased significantly in recent decades, mainly due to excess calorie intake and increasingly sedentary lifestyle. Here, we test the association between obesity measured by body mass index (BMI) and one of the best-known genetic variants showing strong selective pressure: the functional variant in the cis-regulatory element of the lactase gene. We tested this variant since it is presumed to provide nutritional advantage in specific physical and cultural environments. We genetically defined lactase persistence (LP) in 31 720 individuals from eight European population-based studies and one family study by genotyping or imputing the European LP variant (rs4988235). We performed a meta-analysis by pooling the beta-coefficient estimates of the relationship between rs4988235 and BMI from the nine studies and found that the carriers of the allele responsible for LP among Europeans showed higher BMI (P = 7.9 x 10(-5)). Since this locus has been shown to be prone to population stratification, we paid special attention to reveal any population substructure which might be responsible for the association signal. The best evidence of exclusion of stratification came from the Dutch family sample which is robust for stratification. In this study, we highlight issues in model selection in the genome-wide association studies and problems in imputation of these special genomic regions. |
| spellingShingle | Kettunen, J Silander, K Saarela, O Amin, N Müller, M Timpson, N Surakka, I Ripatti, S Laitinen, J Hartikainen, A Pouta, A Lahermo, P Anttila, V Männistö, S Jula, A Virtamo, J Salomaa, V Lehtimäki, T Raitakari, O Gieger, C Wichmann, E Van Duijn, C Smith, G McCarthy, M Järvelin, MR European lactase persistence genotype shows evidence of association with increase in body mass index. |
| title | European lactase persistence genotype shows evidence of association with increase in body mass index. |
| title_full | European lactase persistence genotype shows evidence of association with increase in body mass index. |
| title_fullStr | European lactase persistence genotype shows evidence of association with increase in body mass index. |
| title_full_unstemmed | European lactase persistence genotype shows evidence of association with increase in body mass index. |
| title_short | European lactase persistence genotype shows evidence of association with increase in body mass index. |
| title_sort | european lactase persistence genotype shows evidence of association with increase in body mass index |
| work_keys_str_mv | AT kettunenj europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT silanderk europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT saarelao europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT aminn europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT mullerm europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT timpsonn europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT surakkai europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT ripattis europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT laitinenj europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT hartikainena europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT poutaa europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT lahermop europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT anttilav europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT mannistos europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT julaa europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT virtamoj europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT salomaav europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT lehtimakit europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT raitakario europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT giegerc europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT wichmanne europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT vanduijnc europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT smithg europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT mccarthym europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex AT jarvelinmr europeanlactasepersistencegenotypeshowsevidenceofassociationwithincreaseinbodymassindex |