Characterization of four CD18 mutants in leucocyte adhesion deficient (LAD) patients with differential capacities to support expression and function of the CD11/CD18 integrins LFA-1, Mac-1 and p150,95.

Characterization of four CD18 mutants in leucocyte adhesion deficient (LAD) patients with differential capacities to support expression and function of the CD11/CD18 integrins LFA-1, Mac-1 and p150,95.

Leucocyte adhesion deficiency (LAD) is a hereditary disorder caused by mutations in the CD18 (beta2 integrin) gene. Four missense mutations have been identified in three patients. CD18(A270V) supports, at a diminished level, CD11b/CD18 (Mac-1, alphaMbeta2 integrin) and CD11c/CD18 (p150,95, alphaXbet...

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Bibliographic Details
Main Authors:	Shaw, J, Al-Shamkhani, A, Boxer, L, Buckley, C, Dodds, A, Klein, N, Nolan, S, Roberts, I, Roos, D, Scarth, S, Simmons, D, Tan, S, Law, S
Format:	Journal article
Language:	English
Published:	2001

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