Self-stimulation at the lateral hypothalamus and locus coeruleus after specific unilateral lesions of the dopamine system.
A group of rats was trained to press levers for electrical stimulation from bipolar electrodes aimed at the lateral hypothalamus (LH), and another group was trained to self-stimulate from electrodes in the locus coeruleus (LC). All rats in both groups were subjected to unilateral injections of 6-hyd...
| Asıl Yazarlar: | , , |
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| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
1978
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| _version_ | 1826275527515701248 |
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| author | Koob, G Fray, P Iversen, S |
| author_facet | Koob, G Fray, P Iversen, S |
| author_sort | Koob, G |
| collection | OXFORD |
| description | A group of rats was trained to press levers for electrical stimulation from bipolar electrodes aimed at the lateral hypothalamus (LH), and another group was trained to self-stimulate from electrodes in the locus coeruleus (LC). All rats in both groups were subjected to unilateral injections of 6-hydroxydopamine into the substantia nigra and midbrain ventral tegmentum. The lesions produced profound depletions of dopamine from the ipsilateral frontal cortex, nucleus accumbens/olfactory tubercle, and corpus striatum. Pretreatment with desmethylimipramine prevented loss of noradrenaline in excess of that caused by electrode implantation. The destruction of the dopamine projections produced a persistent and pronounced deficit in intracranial self-stimulation from ipsilateral electrodes in both the LH and LC groups, but only transient effects on self-stimulation from contralateral electrodes at these sites. These results suggest that an intact dopamine system is required for the expression of self-stimulation behaviour. |
| first_indexed | 2024-03-06T23:00:04Z |
| format | Journal article |
| id | oxford-uuid:61cf827b-f453-4f9d-bc35-b358a79afdb7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:00:04Z |
| publishDate | 1978 |
| record_format | dspace |
| spelling | oxford-uuid:61cf827b-f453-4f9d-bc35-b358a79afdb72022-03-26T18:02:12ZSelf-stimulation at the lateral hypothalamus and locus coeruleus after specific unilateral lesions of the dopamine system.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:61cf827b-f453-4f9d-bc35-b358a79afdb7EnglishSymplectic Elements at Oxford1978Koob, GFray, PIversen, SA group of rats was trained to press levers for electrical stimulation from bipolar electrodes aimed at the lateral hypothalamus (LH), and another group was trained to self-stimulate from electrodes in the locus coeruleus (LC). All rats in both groups were subjected to unilateral injections of 6-hydroxydopamine into the substantia nigra and midbrain ventral tegmentum. The lesions produced profound depletions of dopamine from the ipsilateral frontal cortex, nucleus accumbens/olfactory tubercle, and corpus striatum. Pretreatment with desmethylimipramine prevented loss of noradrenaline in excess of that caused by electrode implantation. The destruction of the dopamine projections produced a persistent and pronounced deficit in intracranial self-stimulation from ipsilateral electrodes in both the LH and LC groups, but only transient effects on self-stimulation from contralateral electrodes at these sites. These results suggest that an intact dopamine system is required for the expression of self-stimulation behaviour. |
| spellingShingle | Koob, G Fray, P Iversen, S Self-stimulation at the lateral hypothalamus and locus coeruleus after specific unilateral lesions of the dopamine system. |
| title | Self-stimulation at the lateral hypothalamus and locus coeruleus after specific unilateral lesions of the dopamine system. |
| title_full | Self-stimulation at the lateral hypothalamus and locus coeruleus after specific unilateral lesions of the dopamine system. |
| title_fullStr | Self-stimulation at the lateral hypothalamus and locus coeruleus after specific unilateral lesions of the dopamine system. |
| title_full_unstemmed | Self-stimulation at the lateral hypothalamus and locus coeruleus after specific unilateral lesions of the dopamine system. |
| title_short | Self-stimulation at the lateral hypothalamus and locus coeruleus after specific unilateral lesions of the dopamine system. |
| title_sort | self stimulation at the lateral hypothalamus and locus coeruleus after specific unilateral lesions of the dopamine system |
| work_keys_str_mv | AT koobg selfstimulationatthelateralhypothalamusandlocuscoeruleusafterspecificunilaterallesionsofthedopaminesystem AT frayp selfstimulationatthelateralhypothalamusandlocuscoeruleusafterspecificunilaterallesionsofthedopaminesystem AT iversens selfstimulationatthelateralhypothalamusandlocuscoeruleusafterspecificunilaterallesionsofthedopaminesystem |