Adenovirus-mediated gene transfer of a secreted form of human macrophage scavenger receptor inhibits modified low-density lipoprotein degradation and foam-cell formation in macrophages.

Adenovirus-mediated gene transfer of a secreted form of human macrophage scavenger receptor inhibits modified low-density lipoprotein degradation and foam-cell formation in macrophages.

BACKGROUND: Macrophage scavenger receptors (MSRs) play an important role in the pathogenesis of atherosclerosis. Therefore, local modulation of MSR activity could have a beneficial effect on atherogenesis. METHODS AND RESULTS: We cloned a secreted "decoy" MSR (sMSR) that contains an extrac...

Bibliografski detalji
Glavni autori:	Laukkanen, J, Lehtolainen, P, Gough, P, Greaves, D, Gordon, S, Ylä-Herttuala, S
Format:	Journal article
Jezik:	English
Izdano:	2000

Slični predmeti

Effects of secreted macrophage scavenger receptor on atherogenesis and lipoprotein metabolism in LDL receptor knockout mice
od: Laukkanen, J, i dr.
Izdano: (1999)

Adenovirus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor (SR-AI) in LDL receptor knock-out mice.
od: Jalkanen, J, i dr.
Izdano: (2003)

Rabbit atherosclerotic lesions express scavenger receptor AIII mRNA, a naturally occurring splice variant that encodes a non-functional, dominant negative form of the macrophage scavenger receptor.
od: Hiltunen, T, i dr.
Izdano: (2001)

Analysis of macrophage scavenger receptor (SR-A) expression in human aortic atherosclerotic lesions.
od: Gough, P, i dr.
Izdano: (1999)

A novel alternatively spliced variant of the human macrophage scavenger receptor gene
od: Gough, P, i dr.
Izdano: (1996)

Adeno-associated virus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor reduces atherosclerotic lesion formation in LDL receptor knockout mice.
od: Jalkanen, J, i dr.
Izdano: (2003)

The use of human CD68 transcriptional regulatory sequences to direct high-level expression of class A scavenger receptor in macrophages in vitro and in vivo.
od: Gough, P, i dr.
Izdano: (2001)

A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake.
od: Gough, P, i dr.
Izdano: (1998)

Factors regulating the activities of the low density lipoprotein receptor and the scavenger receptor on human monocyte-macrophages.
od: A M Fogelman, i dr.
Izdano: (1981-09-01)

Isoborneol Attenuates Low-Density Lipoprotein Accumulation and Foam Cell Formation in Macrophages
od: Wang Y, i dr.
Izdano: (2020-01-01)

Adenovirus-mediated gene transfer of Lp-PLA2 reduces LDL degradation and foam cell formation in vitro
od: Päivi Turunen, i dr.
Izdano: (2004-09-01)

The macrophage scavenger receptor at 30 years of age: current knowledge and future challenges.
od: Greaves, D, i dr.
Izdano: (2009)

Increased uptake of α-hydroxy aldehyde-modified low density lipoprotein by macrophage scavenger receptors
od: Mitsunobu Kawamura, i dr.
Izdano: (2000-07-01)

Regulation of apolipoprotein E secretion by high density lipoprotein 3 in mouse macrophages
od: L Dory
Izdano: (1991-05-01)

The macrophage scavenger receptor at 30 years of age: current knowledge and future challenges
od: David R. Greaves, i dr.
Izdano: (2009-01-01)

Development and application of a nonradioactive binding assay of oxidized low-density lipoprotein to macrophage scavenger receptors
od: Erica N. Montano, i dr.
Izdano: (2013-11-01)

Cholesterol deposition in macrophages: foam cell formation mediated by cholesterol-enriched oxidized low density lipoprotein.
od: P Greenspan, i dr.
Izdano: (1997-01-01)

Thematic review series: the immune system and atherogenesis. Recent insights into the biology of macrophage scavenger receptors.
od: Greaves, D, i dr.
Izdano: (2005)

Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages
od: Mareike D. Maler, i dr.
Izdano: (2017-09-01)

A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake1
od: Peter J. Gough, i dr.
Izdano: (1998-03-01)

Lipoproteins of the extravascular space: enhanced macrophage degradation of low density lipoproteins from interstitial inflammatory fluid
od: T L Raymond, i dr.
Izdano: (1985-11-01)

Thematic review series: The Immune System and Atherogenesis. Recent insights into the biology of macrophage scavenger receptors
od: David R. Greaves, i dr.
Izdano: (2005-01-01)

Macrophage scavenger receptors and host-derived ligands.
od: Plüddemann, A, i dr.
Izdano: (2007)

IL-17-differentiated macrophages secrete pro-inflammatory cytokines in response to oxidized low-density lipoprotein
od: María de la Paz Sánchez-Martínez, i dr.
Izdano: (2017-10-01)

High-Density Lipoproteins Are Bug Scavengers
od: Olivier Meilhac, i dr.
Izdano: (2020-04-01)

Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation.
od: Manoj K Barthwal, i dr.
Izdano: (2013-01-01)

Immunohistochemical evidence for a macrophage scavenger receptor in Mato cells and reactive microglia of ischemia and Alzheimer's disease.
od: Honda, M, i dr.
Izdano: (1998)

Myricetin ameliorates atherosclerosis in the low-density-lipoprotein receptor knockout mice by suppression of cholesterol accumulation in macrophage foam cells
od: Zhe Meng, i dr.
Izdano: (2019-04-01)

Amino terminus of apolipoprotein B suffices to produce recognition of malondialdehyde-modified low density lipoprotein by the scavenger receptor of human monocyte-macrophages
od: J Kreuzer, i dr.
Izdano: (1997-02-01)

Recent progress in defining the role of scavenger receptors in lipid transport, atherosclerosis and host defence.
od: Greaves, D, i dr.
Izdano: (1998)

Human macrophages limit oxidation products in low density lipoprotein
od: Dahlgren Claes, i dr.
Izdano: (2005-03-01)

Erratum for Maler et al., “Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages”
od: Mareike D. Maler, i dr.
Izdano: (2017-11-01)

Apigenin-7-O-β-D-glucuronide inhibits modified low-density lipoprotein uptake and foam cell formation in macrophages
od: Qin Ma, i dr.
Izdano: (2017-08-01)

TRAIL/DR5 signaling promotes macrophage foam cell formation by modulating scavenger receptor expression.
od: Fang Fang Liu, i dr.
Izdano: (2014-01-01)

Immunophenotyping of macrophages in human pulmonary tuberculosis and sarcoidosis.
od: Stanton, L, i dr.
Izdano: (2003)

NMR spectroscopy of macrophages loaded with native, oxidized or enzymatically degraded lipoproteins.
od: Paul Ramm Sander, i dr.
Izdano: (2013-01-01)

Macrophage metalloproteinases degrade high-density-lipoprotein-associated apolipoprotein A-I at both the N- and C-termini.
od: Eberini, I, i dr.
Izdano: (2002)

Macrophage metalloproteinases degrade high-density-lipoprotein-associated apolipoprotein A-I at both the N- and C-termini
od: Eberini, I, i dr.
Izdano: (2002)

Characterisation of scavenger receptor MARCO as a marker for macrophage innate activation.
od: Mukhopadhyay, S, i dr.
Izdano: (2005)

Macrophage oxidative modification of low density lipoprotein occurs independently of its binding to the low density lipoprotein receptor
od: R K Tangirala, i dr.
Izdano: (1996-04-01)