Mitophagy plays a central role in mitochondrial ageing
The mechanisms underlying ageing have been discussed for decades, and advances in molecular and cell biology of the last three decades have accelerated research in this area. Over this period, it has become clear that mitochondrial function, which plays a major role in many cellular pathways from AT...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Springer Verlag
2016
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| _version_ | 1826275531308400640 |
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| author | Diot, A Morten, K Poulton, J |
| author_facet | Diot, A Morten, K Poulton, J |
| author_sort | Diot, A |
| collection | OXFORD |
| description | The mechanisms underlying ageing have been discussed for decades, and advances in molecular and cell biology of the last three decades have accelerated research in this area. Over this period, it has become clear that mitochondrial function, which plays a major role in many cellular pathways from ATP production to nuclear gene expression and epigenetics alterations, declines with age. The emerging concepts suggest novel mechanisms, involving mtDNA quality, mitochondrial dynamics or mitochondrial quality control. In this review, we discuss the impact of mitochondria in the ageing process, the role of mitochondria in reactive oxygen species production, in nuclear gene expression, the accumulation of mtDNA damage and the importance of mitochondrial dynamics and recycling. Declining mitophagy (mitochondrial quality control) may be an important component of human ageing. |
| first_indexed | 2024-03-06T23:00:08Z |
| format | Journal article |
| id | oxford-uuid:61d50466-fbdf-4d31-a64d-f37d2c5948e4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:00:08Z |
| publishDate | 2016 |
| publisher | Springer Verlag |
| record_format | dspace |
| spelling | oxford-uuid:61d50466-fbdf-4d31-a64d-f37d2c5948e42022-03-26T18:02:20ZMitophagy plays a central role in mitochondrial ageingJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:61d50466-fbdf-4d31-a64d-f37d2c5948e4EnglishSymplectic Elements at OxfordSpringer Verlag2016Diot, AMorten, KPoulton, JThe mechanisms underlying ageing have been discussed for decades, and advances in molecular and cell biology of the last three decades have accelerated research in this area. Over this period, it has become clear that mitochondrial function, which plays a major role in many cellular pathways from ATP production to nuclear gene expression and epigenetics alterations, declines with age. The emerging concepts suggest novel mechanisms, involving mtDNA quality, mitochondrial dynamics or mitochondrial quality control. In this review, we discuss the impact of mitochondria in the ageing process, the role of mitochondria in reactive oxygen species production, in nuclear gene expression, the accumulation of mtDNA damage and the importance of mitochondrial dynamics and recycling. Declining mitophagy (mitochondrial quality control) may be an important component of human ageing. |
| spellingShingle | Diot, A Morten, K Poulton, J Mitophagy plays a central role in mitochondrial ageing |
| title | Mitophagy plays a central role in mitochondrial ageing |
| title_full | Mitophagy plays a central role in mitochondrial ageing |
| title_fullStr | Mitophagy plays a central role in mitochondrial ageing |
| title_full_unstemmed | Mitophagy plays a central role in mitochondrial ageing |
| title_short | Mitophagy plays a central role in mitochondrial ageing |
| title_sort | mitophagy plays a central role in mitochondrial ageing |
| work_keys_str_mv | AT diota mitophagyplaysacentralroleinmitochondrialageing AT mortenk mitophagyplaysacentralroleinmitochondrialageing AT poultonj mitophagyplaysacentralroleinmitochondrialageing |