UKMenCar4: a cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence
Carriage of Neisseria meningitidis , the meningococcus, is a prerequisite for invasive meningococcal disease (IMD), a potentially devastating infection that disproportionately afflicts infants and children. Humans are the sole known reservoir for the meningococcus, and it is carried asymptomatically...
| Үндсэн зохиолчид: | , , , , , , , , , , , , , , , |
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| Формат: | Journal article |
| Хэвлэсэн: |
F1000 Research
2019
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| _version_ | 1826275534103904256 |
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| author | Bratcher, H Rodrigues, C Finn, A Wootton, M Cameron, C Smith, A Heath, P Ladhani, S Snape, M Pollard, A Cunningham, R Borrow, R Trotter, C Gray, S Maiden, M Maclennan, J |
| author_facet | Bratcher, H Rodrigues, C Finn, A Wootton, M Cameron, C Smith, A Heath, P Ladhani, S Snape, M Pollard, A Cunningham, R Borrow, R Trotter, C Gray, S Maiden, M Maclennan, J |
| author_sort | Bratcher, H |
| collection | OXFORD |
| description | Carriage of Neisseria meningitidis , the meningococcus, is a prerequisite for invasive meningococcal disease (IMD), a potentially devastating infection that disproportionately afflicts infants and children. Humans are the sole known reservoir for the meningococcus, and it is carried asymptomatically in the nasopharynx of ~10% of the population. Rates of carriage are dependent on age of the host and social and behavioural factors. In the UK, meningococcal carriage has been studied through large, multi-centre carriage surveys of adolescents in 1999, 2000, and 2001, demonstrating carriage can be affected by immunisation with the capsular group C meningococcal conjugate vaccine, inducing population immunity against carriage. Fifteen years after these surveys were carried out, invasive meningococcal disease incidence had declined from a peak in 1999. The UKMenCar4 study was conducted in 2014/15 to investigate rates of carriage amongst the adolescent population during a period of low disease incidence. The protocols and methodology used to perform UKMenCar4, a large carriage survey, are described here. |
| first_indexed | 2024-03-06T23:00:11Z |
| format | Journal article |
| id | oxford-uuid:61d7980e-009c-4a8c-8150-0aa534affab7 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:00:11Z |
| publishDate | 2019 |
| publisher | F1000 Research |
| record_format | dspace |
| spelling | oxford-uuid:61d7980e-009c-4a8c-8150-0aa534affab72022-03-26T18:02:30ZUKMenCar4: a cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidenceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:61d7980e-009c-4a8c-8150-0aa534affab7Symplectic Elements at OxfordF1000 Research2019Bratcher, HRodrigues, CFinn, AWootton, MCameron, CSmith, AHeath, PLadhani, SSnape, MPollard, ACunningham, RBorrow, RTrotter, CGray, SMaiden, MMaclennan, JCarriage of Neisseria meningitidis , the meningococcus, is a prerequisite for invasive meningococcal disease (IMD), a potentially devastating infection that disproportionately afflicts infants and children. Humans are the sole known reservoir for the meningococcus, and it is carried asymptomatically in the nasopharynx of ~10% of the population. Rates of carriage are dependent on age of the host and social and behavioural factors. In the UK, meningococcal carriage has been studied through large, multi-centre carriage surveys of adolescents in 1999, 2000, and 2001, demonstrating carriage can be affected by immunisation with the capsular group C meningococcal conjugate vaccine, inducing population immunity against carriage. Fifteen years after these surveys were carried out, invasive meningococcal disease incidence had declined from a peak in 1999. The UKMenCar4 study was conducted in 2014/15 to investigate rates of carriage amongst the adolescent population during a period of low disease incidence. The protocols and methodology used to perform UKMenCar4, a large carriage survey, are described here. |
| spellingShingle | Bratcher, H Rodrigues, C Finn, A Wootton, M Cameron, C Smith, A Heath, P Ladhani, S Snape, M Pollard, A Cunningham, R Borrow, R Trotter, C Gray, S Maiden, M Maclennan, J UKMenCar4: a cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence |
| title | UKMenCar4: a cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence |
| title_full | UKMenCar4: a cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence |
| title_fullStr | UKMenCar4: a cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence |
| title_full_unstemmed | UKMenCar4: a cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence |
| title_short | UKMenCar4: a cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence |
| title_sort | ukmencar4 a cross sectional survey of asymptomatic meningococcal carriage amongst uk adolescents at a period of low invasive meningococcal disease incidence |
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