Functional lung assessment using hyperpolarised xenon gas magnetic resonance imaging
<p><b>Purpose</b></p> <p>Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. The standard method for assessing lung function in COPD is spirometry, which provides <em>global</em> lung function information but is a poor pre...
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| Format: | Thesis |
| Language: | English |
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2016
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| _version_ | 1797071932324052992 |
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| author | Matin, T |
| author2 | Gleeson, F |
| author_facet | Gleeson, F Matin, T |
| author_sort | Matin, T |
| collection | OXFORD |
| description | <p><b>Purpose</b></p> <p>Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. The standard method for assessing lung function in COPD is spirometry, which provides <em>global</em> lung function information but is a poor predictor of disability and quality of life. The overall aim of this thesis is to develop utility of hyperpolarised xenon gas magnetic resonance imaging (HP <sup>129</sup>Xe-MRI) as a technique to evaluate <em>regional</em> lung function.</p> <p><b>Methods</b></p> <p>Studies were approved by the National Research Ethics Service (NRES). Eleven volunteers and 25 patients with COPD underwent HP <sup>129</sup>Xe-MRI, pulmonary function tests (PFTs) and quantitative computerised tomography (QCT). Gravitational-dependent gradients of HP <sup>129</sup>Xe-MRI were compared between prone and supine postures in healthy volunteers. Lobar quantification of HP <sup>129</sup>Xe-MRI was completed in COPD patients, who also underwent time-resolved HP <sup>129</sup>Xe-MRI and HP <sup>129</sup>Xe-MRI pre- and post-salbutamol to determine feasibility of detecting regional delayed ventilation and post-intervention change. The relationship between study measures was assessed using Pearson’s correlation coefficient.</p> <p><b>Results</b></p> <p>HP <sup>129</sup>Xe-MR ventilation gradients were more marked in the supine than prone posture in healthy volunteers, whereas diffusion-weighted gradients were more uniform. HP <sup>129</sup>Xe-MRI was successfully quantified according to pulmonary lobes and correlated with lobar lung anatomy (QCT) and global functional transfer capability (TLCO) (<em>r</em>=-0.61, p&LT;0.005). Delayed ventilation was observed with time-resolved breath-hold HP <sup>129</sup>Xe-MRI. Differential regional ventilation change was detected with HP <sup>129</sup>Xe-MRI post-salbutamol.</p> <p><b>Conclusion</b></p> <p>These data demonstrate technical optimisation of HP <sup>129</sup>Xe-MRI in healthy volunteers and COPD patients. Successful generation of lobar HP <sup>129</sup>Xe-MRI parameters offers an automated analysis method that can be adopted into the clinical workflow. Finally proof-of-principle data have identified roles for HP <sup>129</sup>Xe-MRI in evaluating regional treatments and assessing therapeutic response. Future work will evaluate the role of HP <sup>129</sup>Xe-MRI in patient selection for lung volume reduction therapy and as a surrogate end-point in drug development studies. </p> |
| first_indexed | 2024-03-06T23:00:24Z |
| format | Thesis |
| id | oxford-uuid:61e77bfb-67d9-4221-b246-4a5cd66b5144 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:00:24Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | oxford-uuid:61e77bfb-67d9-4221-b246-4a5cd66b51442022-03-26T18:02:55ZFunctional lung assessment using hyperpolarised xenon gas magnetic resonance imagingThesishttp://purl.org/coar/resource_type/c_db06uuid:61e77bfb-67d9-4221-b246-4a5cd66b5144Magnetic resonance imagingPulmonary functionEnglishORA Deposit2016Matin, TGleeson, F<p><b>Purpose</b></p> <p>Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. The standard method for assessing lung function in COPD is spirometry, which provides <em>global</em> lung function information but is a poor predictor of disability and quality of life. The overall aim of this thesis is to develop utility of hyperpolarised xenon gas magnetic resonance imaging (HP <sup>129</sup>Xe-MRI) as a technique to evaluate <em>regional</em> lung function.</p> <p><b>Methods</b></p> <p>Studies were approved by the National Research Ethics Service (NRES). Eleven volunteers and 25 patients with COPD underwent HP <sup>129</sup>Xe-MRI, pulmonary function tests (PFTs) and quantitative computerised tomography (QCT). Gravitational-dependent gradients of HP <sup>129</sup>Xe-MRI were compared between prone and supine postures in healthy volunteers. Lobar quantification of HP <sup>129</sup>Xe-MRI was completed in COPD patients, who also underwent time-resolved HP <sup>129</sup>Xe-MRI and HP <sup>129</sup>Xe-MRI pre- and post-salbutamol to determine feasibility of detecting regional delayed ventilation and post-intervention change. The relationship between study measures was assessed using Pearson’s correlation coefficient.</p> <p><b>Results</b></p> <p>HP <sup>129</sup>Xe-MR ventilation gradients were more marked in the supine than prone posture in healthy volunteers, whereas diffusion-weighted gradients were more uniform. HP <sup>129</sup>Xe-MRI was successfully quantified according to pulmonary lobes and correlated with lobar lung anatomy (QCT) and global functional transfer capability (TLCO) (<em>r</em>=-0.61, p&LT;0.005). Delayed ventilation was observed with time-resolved breath-hold HP <sup>129</sup>Xe-MRI. Differential regional ventilation change was detected with HP <sup>129</sup>Xe-MRI post-salbutamol.</p> <p><b>Conclusion</b></p> <p>These data demonstrate technical optimisation of HP <sup>129</sup>Xe-MRI in healthy volunteers and COPD patients. Successful generation of lobar HP <sup>129</sup>Xe-MRI parameters offers an automated analysis method that can be adopted into the clinical workflow. Finally proof-of-principle data have identified roles for HP <sup>129</sup>Xe-MRI in evaluating regional treatments and assessing therapeutic response. Future work will evaluate the role of HP <sup>129</sup>Xe-MRI in patient selection for lung volume reduction therapy and as a surrogate end-point in drug development studies. </p> |
| spellingShingle | Magnetic resonance imaging Pulmonary function Matin, T Functional lung assessment using hyperpolarised xenon gas magnetic resonance imaging |
| title | Functional lung assessment using hyperpolarised xenon gas magnetic resonance imaging |
| title_full | Functional lung assessment using hyperpolarised xenon gas magnetic resonance imaging |
| title_fullStr | Functional lung assessment using hyperpolarised xenon gas magnetic resonance imaging |
| title_full_unstemmed | Functional lung assessment using hyperpolarised xenon gas magnetic resonance imaging |
| title_short | Functional lung assessment using hyperpolarised xenon gas magnetic resonance imaging |
| title_sort | functional lung assessment using hyperpolarised xenon gas magnetic resonance imaging |
| topic | Magnetic resonance imaging Pulmonary function |
| work_keys_str_mv | AT matint functionallungassessmentusinghyperpolarisedxenongasmagneticresonanceimaging |