Raltitrexed (Tomudex) versus standard leucovorin-modulated bolus 5-fluorouracil: Results from the randomised phase III Pan-European Trial in Adjuvant Colon Cancer 01 (PETACC-1).

Raltitrexed (Tomudex) versus standard leucovorin-modulated bolus 5-fluorouracil: Results from the randomised phase III Pan-European Trial in Adjuvant Colon Cancer 01 (PETACC-1).

OBJECTIVES: PETACC-1 assessed if raltitrexed is non-inferior to 5-fluorouracil and leucovorin for relapse-free survival (RFS) and overall survival (OS) in adjuvant stage III colon cancer. METHODS: Non-inferiority required both HR for RFS and OS<1.25 at 1-sided alpha=0.05. Patients (1921) wer...

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Bibliographic Details
Main Authors:	Popov, I, Carrato, A, Sobrero, A, Vincent, M, Kerr, D, Labianca, R, Raffaele Bianco, A, El-Serafi, M, Bedenne, L, Paillot, B, Mini, E, Sanches, E, Welch, J, Collette, L, Praet, M, Wils, J
Format:	Journal article
Language:	English
Published:	2008

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