Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naive CD4+ T cells via blood vessels and lymphatics.
The tumor microenvironment comprises newly formed blood and lymphatic vessels which shape the influx, retention and departure of lymphocytes within the tumor mass. Thus, by influencing the intratumoral composition of lymphocytes, these vessels affect the manner in which the adaptive immune system re...
| Autori principali: | , , , , , , , , , , , , |
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| Natura: | Journal article |
| Lingua: | English |
| Pubblicazione: |
John Wiley and Sons
2014
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| _version_ | 1826275626370203648 |
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| author | Ondondo, B Jones, E Hindley, J Cutting, S Smart, K Bridgeman, H Matthews, K Ladell, K Price, D Jackson, D Godkin, A Ager, A Gallimore, A |
| author_facet | Ondondo, B Jones, E Hindley, J Cutting, S Smart, K Bridgeman, H Matthews, K Ladell, K Price, D Jackson, D Godkin, A Ager, A Gallimore, A |
| author_sort | Ondondo, B |
| collection | OXFORD |
| description | The tumor microenvironment comprises newly formed blood and lymphatic vessels which shape the influx, retention and departure of lymphocytes within the tumor mass. Thus, by influencing the intratumoral composition of lymphocytes, these vessels affect the manner in which the adaptive immune system responds to the tumor, either promoting or impairing effective antitumor immunity. In our study, we utilized a mouse model of carcinogen-induced fibrosarcoma to examine the composition of tumor-infiltrating lymphocytes during tumor progression. In particular, we sought to determine whether CD4(+) Foxp3(+) regulatory T cells (Tregs) became enriched during tumor progression thereby contributing to tumor-driven immunosuppression. This was not the case as the proportion of Tregs and effector CD4(+) T cells actually declined within the tumor owing to the unexpected accumulation of naïve T cells. However, we found no evidence for antigen-driven migration of these T cells or for their participation in an antitumor immune response. Our data support the notion that lymphocytes can enter tumors via aberrantly formed blood and lymphatic vessels. Such findings suggest that targeting both the tumor vasculature and lymphatics will alter the balance of lymphocyte subpopulations that enter the tumor mass. A consideration of this aspect of tumor immunology may be critical to the success of solid cancer immunotherapies. |
| first_indexed | 2024-03-06T23:01:38Z |
| format | Journal article |
| id | oxford-uuid:62545481-5637-450a-8f23-661763596c77 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:01:38Z |
| publishDate | 2014 |
| publisher | John Wiley and Sons |
| record_format | dspace |
| spelling | oxford-uuid:62545481-5637-450a-8f23-661763596c772022-03-26T18:05:39ZProgression of carcinogen-induced fibrosarcomas is associated with the accumulation of naive CD4+ T cells via blood vessels and lymphatics.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:62545481-5637-450a-8f23-661763596c77EnglishSymplectic Elements at OxfordJohn Wiley and Sons2014Ondondo, BJones, EHindley, JCutting, SSmart, KBridgeman, HMatthews, KLadell, KPrice, DJackson, DGodkin, AAger, AGallimore, AThe tumor microenvironment comprises newly formed blood and lymphatic vessels which shape the influx, retention and departure of lymphocytes within the tumor mass. Thus, by influencing the intratumoral composition of lymphocytes, these vessels affect the manner in which the adaptive immune system responds to the tumor, either promoting or impairing effective antitumor immunity. In our study, we utilized a mouse model of carcinogen-induced fibrosarcoma to examine the composition of tumor-infiltrating lymphocytes during tumor progression. In particular, we sought to determine whether CD4(+) Foxp3(+) regulatory T cells (Tregs) became enriched during tumor progression thereby contributing to tumor-driven immunosuppression. This was not the case as the proportion of Tregs and effector CD4(+) T cells actually declined within the tumor owing to the unexpected accumulation of naïve T cells. However, we found no evidence for antigen-driven migration of these T cells or for their participation in an antitumor immune response. Our data support the notion that lymphocytes can enter tumors via aberrantly formed blood and lymphatic vessels. Such findings suggest that targeting both the tumor vasculature and lymphatics will alter the balance of lymphocyte subpopulations that enter the tumor mass. A consideration of this aspect of tumor immunology may be critical to the success of solid cancer immunotherapies. |
| spellingShingle | Ondondo, B Jones, E Hindley, J Cutting, S Smart, K Bridgeman, H Matthews, K Ladell, K Price, D Jackson, D Godkin, A Ager, A Gallimore, A Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naive CD4+ T cells via blood vessels and lymphatics. |
| title | Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naive CD4+ T cells via blood vessels and lymphatics. |
| title_full | Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naive CD4+ T cells via blood vessels and lymphatics. |
| title_fullStr | Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naive CD4+ T cells via blood vessels and lymphatics. |
| title_full_unstemmed | Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naive CD4+ T cells via blood vessels and lymphatics. |
| title_short | Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naive CD4+ T cells via blood vessels and lymphatics. |
| title_sort | progression of carcinogen induced fibrosarcomas is associated with the accumulation of naive cd4 t cells via blood vessels and lymphatics |
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