Immunosuppression associated with interleukin-1R-associated-kinase-M upregulation predicts mortality in Gram-negative sepsis (melioidosis).

Immunosuppression associated with interleukin-1R-associated-kinase-M upregulation predicts mortality in Gram-negative sepsis (melioidosis).

OBJECTIVES: Sepsis is associated with immunosuppression (characterized by a reduced capacity of circulating monocytes to release proinflammatory cytokines), which has been implicated in late mortality. Melioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, is an important caus...

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Bibliographic Details
Main Authors: Wiersinga, W, van't Veer, C, van den Pangaart, P, Dondorp, A, Day, N, Peacock, S, van der Poll, T
Format: Journal article
Language:English
Published: 2009

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