The CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and beta 2-microglobulin-free HLA-G molecules.
For a proper development of the placenta, maternal NK cells should not attack the fetal extravillous cytotrophoblast cells. This inhibition of maternal NK cells is partially mediated via the nonclassical MHC class I molecule HLA-G. Recently, we demonstrated that HLA-G forms disulfide-linked high mol...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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| _version_ | 1826275656218968064 |
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| author | Gonen-Gross, T Achdout, H Arnon, T Gazit, R Stern, N Horejsí, V Goldman-Wohl, D Yagel, S Mandelboim, O |
| author_facet | Gonen-Gross, T Achdout, H Arnon, T Gazit, R Stern, N Horejsí, V Goldman-Wohl, D Yagel, S Mandelboim, O |
| author_sort | Gonen-Gross, T |
| collection | OXFORD |
| description | For a proper development of the placenta, maternal NK cells should not attack the fetal extravillous cytotrophoblast cells. This inhibition of maternal NK cells is partially mediated via the nonclassical MHC class I molecule HLA-G. Recently, we demonstrated that HLA-G forms disulfide-linked high molecular complexes on the surface of transfected cells. In the present study, we demonstrate that HLA-G must associate with beta(2)m for its interaction with CD85J/leukocyte Ig-like receptor-1 (LIR-1). Although HLA-G free H chain complexes are expressed on the surface, they are not recognized and possibly interfere with CD85J/LIR-1 and HLA-G interaction. The formation of these complexes on the cell surface might represent a novel mechanism developed specifically by the HLA-G protein aimed to control the efficiency of the CD85J/LIR-1-mediated inhibition. We also show that endogenous HLA-G complexes are expressed on the cell surface. These findings provide novel insights into the delicate interaction between extravillous cytotrophoblast cells and NK cells in the decidua. |
| first_indexed | 2024-03-06T23:02:06Z |
| format | Journal article |
| id | oxford-uuid:627c7aea-1ee5-46d3-a568-d921a4a53aeb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:02:06Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:627c7aea-1ee5-46d3-a568-d921a4a53aeb2022-03-26T18:06:35ZThe CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and beta 2-microglobulin-free HLA-G molecules.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:627c7aea-1ee5-46d3-a568-d921a4a53aebEnglishSymplectic Elements at Oxford2005Gonen-Gross, TAchdout, HArnon, TGazit, RStern, NHorejsí, VGoldman-Wohl, DYagel, SMandelboim, OFor a proper development of the placenta, maternal NK cells should not attack the fetal extravillous cytotrophoblast cells. This inhibition of maternal NK cells is partially mediated via the nonclassical MHC class I molecule HLA-G. Recently, we demonstrated that HLA-G forms disulfide-linked high molecular complexes on the surface of transfected cells. In the present study, we demonstrate that HLA-G must associate with beta(2)m for its interaction with CD85J/leukocyte Ig-like receptor-1 (LIR-1). Although HLA-G free H chain complexes are expressed on the surface, they are not recognized and possibly interfere with CD85J/LIR-1 and HLA-G interaction. The formation of these complexes on the cell surface might represent a novel mechanism developed specifically by the HLA-G protein aimed to control the efficiency of the CD85J/LIR-1-mediated inhibition. We also show that endogenous HLA-G complexes are expressed on the cell surface. These findings provide novel insights into the delicate interaction between extravillous cytotrophoblast cells and NK cells in the decidua. |
| spellingShingle | Gonen-Gross, T Achdout, H Arnon, T Gazit, R Stern, N Horejsí, V Goldman-Wohl, D Yagel, S Mandelboim, O The CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and beta 2-microglobulin-free HLA-G molecules. |
| title | The CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and beta 2-microglobulin-free HLA-G molecules. |
| title_full | The CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and beta 2-microglobulin-free HLA-G molecules. |
| title_fullStr | The CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and beta 2-microglobulin-free HLA-G molecules. |
| title_full_unstemmed | The CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and beta 2-microglobulin-free HLA-G molecules. |
| title_short | The CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and beta 2-microglobulin-free HLA-G molecules. |
| title_sort | cd85j leukocyte inhibitory receptor 1 distinguishes between conformed and beta 2 microglobulin free hla g molecules |
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