Adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension.
OBJECTIVES: We hypothesized that simultaneous presence of obesity and hypertension activates adaptive vascular mechanisms affecting dilations of human coronary arterioles. METHODS AND RESULTS: Agonist-induced dilations were assessed in isolated pressurized coronary arterioles from patients (n=38) w...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1826275659635228672 |
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| author | Fulop, T Jebelovszki, E Erdei, N Szerafin, T Forster, T Edes, I Koller, A Bagi, Z |
| author_facet | Fulop, T Jebelovszki, E Erdei, N Szerafin, T Forster, T Edes, I Koller, A Bagi, Z |
| author_sort | Fulop, T |
| collection | OXFORD |
| description | OBJECTIVES: We hypothesized that simultaneous presence of obesity and hypertension activates adaptive vascular mechanisms affecting dilations of human coronary arterioles. METHODS AND RESULTS: Agonist-induced dilations were assessed in isolated pressurized coronary arterioles from patients (n=38) who underwent cardiac surgery. Among normotensives we found that dilations to bradykinin (BK) and the NO-donor, sodium-nitroprusside (SNP) were reduced in obese subjects (BK, 10(-7) mol/L, lean: 90+/-4%, obese: 64+/-7%; SNP, 10(-6) mol/L, lean: 89+/-7%, obese: 76+/-5%). However, among hypertensives, both BK- and SNP-induced dilations were significantly enhanced in obese patients, when compared with lean individuals (BK, lean: 71+/-7%, obese: 85+/-3%; SNP, lean: 60+/-6%, obese: 83+/-2%). Correspondingly, in hypertensive patients, but not in those of normotensives, a positive correlation was found between body mass index (BMI) and BK-induced (P=0.036, r=0.46), and also SNP-evoked (P=0.031, r=0.44) coronary dilations. Moreover, in additional 55 hypertensive patients flow-mediated (FMD) and nitroglycerin (NTG)-induced dilations of the brachial artery were assessed. In obese hypertensive individuals, FMD- and NTG-induced dilations were greater (FMD: 6.2+/-0.7%, NTG: 17.2+/-0.9%), than in lean hypertensive patients (FMD: 3.7+/-0.6%, NTG: 13.6+/-1.1%). Correspondingly, FMD- and NTG-induced dilations were positively correlated with BMI (P=0.020, r=0.31 and P=0.033, r=0.29, respectively). CONCLUSIONS: These findings are the first to suggest that obesity may lead to activation of adaptive vascular mechanisms to enhance the dilator function of coronary and peripheral arterial vessels in hypertensive patients. |
| first_indexed | 2024-03-06T23:02:09Z |
| format | Journal article |
| id | oxford-uuid:628257bc-ae52-4a69-83e7-914c255279ac |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:02:09Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:628257bc-ae52-4a69-83e7-914c255279ac2022-03-26T18:06:42ZAdaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:628257bc-ae52-4a69-83e7-914c255279acEnglishSymplectic Elements at Oxford2007Fulop, TJebelovszki, EErdei, NSzerafin, TForster, TEdes, IKoller, ABagi, Z OBJECTIVES: We hypothesized that simultaneous presence of obesity and hypertension activates adaptive vascular mechanisms affecting dilations of human coronary arterioles. METHODS AND RESULTS: Agonist-induced dilations were assessed in isolated pressurized coronary arterioles from patients (n=38) who underwent cardiac surgery. Among normotensives we found that dilations to bradykinin (BK) and the NO-donor, sodium-nitroprusside (SNP) were reduced in obese subjects (BK, 10(-7) mol/L, lean: 90+/-4%, obese: 64+/-7%; SNP, 10(-6) mol/L, lean: 89+/-7%, obese: 76+/-5%). However, among hypertensives, both BK- and SNP-induced dilations were significantly enhanced in obese patients, when compared with lean individuals (BK, lean: 71+/-7%, obese: 85+/-3%; SNP, lean: 60+/-6%, obese: 83+/-2%). Correspondingly, in hypertensive patients, but not in those of normotensives, a positive correlation was found between body mass index (BMI) and BK-induced (P=0.036, r=0.46), and also SNP-evoked (P=0.031, r=0.44) coronary dilations. Moreover, in additional 55 hypertensive patients flow-mediated (FMD) and nitroglycerin (NTG)-induced dilations of the brachial artery were assessed. In obese hypertensive individuals, FMD- and NTG-induced dilations were greater (FMD: 6.2+/-0.7%, NTG: 17.2+/-0.9%), than in lean hypertensive patients (FMD: 3.7+/-0.6%, NTG: 13.6+/-1.1%). Correspondingly, FMD- and NTG-induced dilations were positively correlated with BMI (P=0.020, r=0.31 and P=0.033, r=0.29, respectively). CONCLUSIONS: These findings are the first to suggest that obesity may lead to activation of adaptive vascular mechanisms to enhance the dilator function of coronary and peripheral arterial vessels in hypertensive patients. |
| spellingShingle | Fulop, T Jebelovszki, E Erdei, N Szerafin, T Forster, T Edes, I Koller, A Bagi, Z Adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension. |
| title | Adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension. |
| title_full | Adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension. |
| title_fullStr | Adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension. |
| title_full_unstemmed | Adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension. |
| title_short | Adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension. |
| title_sort | adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension |
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