[Experimental and clinical possibilities of MR spectroscopy of the heart]
MR-spectroscopy of the heart is a relatively new technique for the study of various aspects of cardiac metabolism. The majority of results has so far been obtained with the isolated perfused heart. Here, 31P-MR spectroscopy can be employed to measure high-energy phosphate metabolism and intracellula...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | German |
| Published: |
1991
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| _version_ | 1826275674377158656 |
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| author | Neubauer, S Ertl, G Krahe, T Schindler, R Hillenbrand, H Lackner, K Kochsiek, K |
| author_facet | Neubauer, S Ertl, G Krahe, T Schindler, R Hillenbrand, H Lackner, K Kochsiek, K |
| author_sort | Neubauer, S |
| collection | OXFORD |
| description | MR-spectroscopy of the heart is a relatively new technique for the study of various aspects of cardiac metabolism. The majority of results has so far been obtained with the isolated perfused heart. Here, 31P-MR spectroscopy can be employed to measure high-energy phosphate metabolism and intracellular pH repeatedly and non-invasively. Using a technique called saturation transfer, velocities of enzymatic reactions, such as the creatine kinase reaction, can be measured. Intra- and extracellular Na+ and K+ concentrations can be registered with 23Na- and 39K-MR in conjunction with shift reagent. 13C-MR can be used to tackle carbohydrate metabolism. In-situ-R-spectroscopy allows determination of high-energy phosphates in intact large mammals. Clinical applications of MR-spectroscopy remain to be defined; preliminary results indicate high diagnostic and prognostic potential for patients with coronary artery disease and congestive heart failure. |
| first_indexed | 2024-03-06T23:02:22Z |
| format | Journal article |
| id | oxford-uuid:6297116e-5662-441a-b93e-d6fe28656e8d |
| institution | University of Oxford |
| language | German |
| last_indexed | 2024-03-06T23:02:22Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:6297116e-5662-441a-b93e-d6fe28656e8d2022-03-26T18:07:13Z[Experimental and clinical possibilities of MR spectroscopy of the heart]Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6297116e-5662-441a-b93e-d6fe28656e8dGermanSymplectic Elements at Oxford1991Neubauer, SErtl, GKrahe, TSchindler, RHillenbrand, HLackner, KKochsiek, KMR-spectroscopy of the heart is a relatively new technique for the study of various aspects of cardiac metabolism. The majority of results has so far been obtained with the isolated perfused heart. Here, 31P-MR spectroscopy can be employed to measure high-energy phosphate metabolism and intracellular pH repeatedly and non-invasively. Using a technique called saturation transfer, velocities of enzymatic reactions, such as the creatine kinase reaction, can be measured. Intra- and extracellular Na+ and K+ concentrations can be registered with 23Na- and 39K-MR in conjunction with shift reagent. 13C-MR can be used to tackle carbohydrate metabolism. In-situ-R-spectroscopy allows determination of high-energy phosphates in intact large mammals. Clinical applications of MR-spectroscopy remain to be defined; preliminary results indicate high diagnostic and prognostic potential for patients with coronary artery disease and congestive heart failure. |
| spellingShingle | Neubauer, S Ertl, G Krahe, T Schindler, R Hillenbrand, H Lackner, K Kochsiek, K [Experimental and clinical possibilities of MR spectroscopy of the heart] |
| title | [Experimental and clinical possibilities of MR spectroscopy of the heart] |
| title_full | [Experimental and clinical possibilities of MR spectroscopy of the heart] |
| title_fullStr | [Experimental and clinical possibilities of MR spectroscopy of the heart] |
| title_full_unstemmed | [Experimental and clinical possibilities of MR spectroscopy of the heart] |
| title_short | [Experimental and clinical possibilities of MR spectroscopy of the heart] |
| title_sort | experimental and clinical possibilities of mr spectroscopy of the heart |
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