Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds.

Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds.

Exploiting epigenetics: 2-Oxoglutarate (2OG)-dependent histone lysine demethylases, such as JMJD2E, are potential therapeutic targets in a range of diseases. Through structure-activity relationship studies and analyses, we identified a potent 4-carboxy-2,2'-bipyridyl compound, which inhibits JM...

Bibliográfalaš dieđut
Váldodahkkit:	Chang, K, King, O, Tumber, A, Woon, E, Heightman, T, McDonough, M, Schofield, C, Rose, N
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2011

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