Cyclin F–EXO1 axis controls cell cycle–dependent execution of double-strand break repair

<p>Ubiquitination is a crucial posttranslational modification required for the proper repair of DNA double-strand breaks (DSBs) induced by ionizing radiation (IR). DSBs are mainly repaired through homologous recombination (HR) when template DNA is present and nonhomologous end joining (NHEJ) i...

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Main Authors: Yang, H, Fouad, S, Smith, P, Bae, EY, Ji, Y, Lan, X, Van Ess, A, Buffa, FM, Fischer, R, Vendrell, I, Kessler, BM, D’Angiolella, V
פורמט: Journal article
שפה:English
יצא לאור: American Association for the Advancement of Science 2024