A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate

A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate

Background: Owing to its role in cancer, the phosphoinositide 3-kinase (PI3K)/Akt pathway is an attractive target for therapeutic intervention. We previously reported that the inhibition of Akt by inositol 1,3,4,5,6- pentakisphosphate (InsP5) results in anti-tumour properties. To further develop thi...

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Chi tiết về thư mục
Những tác giả chính:	Falasca, M, Chiozzotto, D, Godage, H, Mazzoletti, M, Riley, A, Previdi, S, Potter, B, Broggini, M, Maffucci, T
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	Nature Publishing Group 2010

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