Identification of phosphorylation sites within the herpes simplex virus tegument protein VP22.

Identification of phosphorylation sites within the herpes simplex virus tegument protein VP22.

The herpes simplex virus protein VP22 is a major phosphoprotein of infected cells. In this study, we identify two serine phosphorylation sites within VP22 and show that the N-terminal site is a substrate for casein kinase II, while the extreme C-terminal site is a substrate for another, as yet unide...

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Príomhchruthaitheoirí: Elliott, G, O'Reilly, D, O'Hare, P
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 1999
Cur síos
Achoimre:The herpes simplex virus protein VP22 is a major phosphoprotein of infected cells. In this study, we identify two serine phosphorylation sites within VP22 and show that the N-terminal site is a substrate for casein kinase II, while the extreme C-terminal site is a substrate for another, as yet unidentified, cellular kinase. Furthermore, we show that a mutant of VP22 which has both sites altered is unable to incorporate phosphate in vivo, confirming that there are no other phosphorylation sites within VP22.

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