Slow wave sleep in humans: role of 5-HT2A and 5-HT2C receptors.
We studied the effects of the 5-HT2 receptor antagonists, ritanserin and ketanserin, on the sleep of healthy volunteers in order to clarify the role of 5-HT2A and 5-HT2C receptors in the regulation of slow wave sleep (SWS) in humans. Ritanserin, 5 mg, produced a substantially larger increase in SWS...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1994
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| _version_ | 1826275713245773824 |
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| author | Sharpley, A Elliott, J Attenburrow, M Cowen, P |
| author_facet | Sharpley, A Elliott, J Attenburrow, M Cowen, P |
| author_sort | Sharpley, A |
| collection | OXFORD |
| description | We studied the effects of the 5-HT2 receptor antagonists, ritanserin and ketanserin, on the sleep of healthy volunteers in order to clarify the role of 5-HT2A and 5-HT2C receptors in the regulation of slow wave sleep (SWS) in humans. Ritanserin, 5 mg, produced a substantially larger increase in SWS (51.4%) than either ketanserin, 20 mg (17.2%) or ketanserin, 40 mg (24.4%). Ritanserin has a significantly higher affinity than ketanserin for 5-HT2C receptor binding sites in the human brain and, based on estimates of per cent occupancy by the two compounds at brain 5-HT2A and 5-HT2C receptors, we conclude that SWS in humans is primarily regulated by 5-HT2C receptors. |
| first_indexed | 2024-03-06T23:02:58Z |
| format | Journal article |
| id | oxford-uuid:62ce4748-c3cc-4944-bcff-a5c8c70e5227 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:02:58Z |
| publishDate | 1994 |
| record_format | dspace |
| spelling | oxford-uuid:62ce4748-c3cc-4944-bcff-a5c8c70e52272022-03-26T18:08:39ZSlow wave sleep in humans: role of 5-HT2A and 5-HT2C receptors.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:62ce4748-c3cc-4944-bcff-a5c8c70e5227EnglishSymplectic Elements at Oxford1994Sharpley, AElliott, JAttenburrow, MCowen, PWe studied the effects of the 5-HT2 receptor antagonists, ritanserin and ketanserin, on the sleep of healthy volunteers in order to clarify the role of 5-HT2A and 5-HT2C receptors in the regulation of slow wave sleep (SWS) in humans. Ritanserin, 5 mg, produced a substantially larger increase in SWS (51.4%) than either ketanserin, 20 mg (17.2%) or ketanserin, 40 mg (24.4%). Ritanserin has a significantly higher affinity than ketanserin for 5-HT2C receptor binding sites in the human brain and, based on estimates of per cent occupancy by the two compounds at brain 5-HT2A and 5-HT2C receptors, we conclude that SWS in humans is primarily regulated by 5-HT2C receptors. |
| spellingShingle | Sharpley, A Elliott, J Attenburrow, M Cowen, P Slow wave sleep in humans: role of 5-HT2A and 5-HT2C receptors. |
| title | Slow wave sleep in humans: role of 5-HT2A and 5-HT2C receptors. |
| title_full | Slow wave sleep in humans: role of 5-HT2A and 5-HT2C receptors. |
| title_fullStr | Slow wave sleep in humans: role of 5-HT2A and 5-HT2C receptors. |
| title_full_unstemmed | Slow wave sleep in humans: role of 5-HT2A and 5-HT2C receptors. |
| title_short | Slow wave sleep in humans: role of 5-HT2A and 5-HT2C receptors. |
| title_sort | slow wave sleep in humans role of 5 ht2a and 5 ht2c receptors |
| work_keys_str_mv | AT sharpleya slowwavesleepinhumansroleof5ht2aand5ht2creceptors AT elliottj slowwavesleepinhumansroleof5ht2aand5ht2creceptors AT attenburrowm slowwavesleepinhumansroleof5ht2aand5ht2creceptors AT cowenp slowwavesleepinhumansroleof5ht2aand5ht2creceptors |