Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain

Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain

The multi-domain enzyme phenylalanine hydroxylase (PAH) catalyzes the hydroxylation of dietary I-phenylalanine (Phe) to I-tyrosine. Inherited mutations that result in PAH enzyme deficiency are the genetic cause of the autosomal recessive disorder phenylketonuria. Phe is the substrate for the PAH act...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Patel, D, Kopec, J, Fitzpatrick, F, McCorvie, T, Yue, W
Μορφή:	Journal article
Έκδοση:	Nature Publishing Group 2016

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