Modelling cerebrovascular pathology and the spread of amyloid beta in Alzheimer’s disease

Alzheimer’s disease is characterised by the accumulation and spread of the amyloid beta protein in the brain. Experiments have revealed that amyloid beta oligomers induce microvascular mural cells to contract, thereby constricting capillaries and increasing resistance to blood flow. Conversely, hypo...

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Hlavní autoři: Ahern, A, Thompson, TB, Oliveri, H, Lorthois, S, Goriely, A
Médium: Journal article
Jazyk:English
Vydáno: Royal Society 2025