Cdc42 promotes transendothelial migration of cancer cells through β1 integrin.

Cdc42 promotes transendothelial migration of cancer cells through β1 integrin.

Cancer cells interact with endothelial cells during the process of metastatic spreading. Here, we use a small interfering RNA screen targeting Rho GTPases in cancer cells to identify Cdc42 as a critical regulator of cancer cell-endothelial cell interactions and transendothelial migration. We find th...

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Bibliographic Details
Main Authors:	Reymond, N, Im, J, Garg, R, Vega, F, Borda d'Agua, B, Riou, P, Cox, S, Valderrama, F, Muschel, R, Ridley, A
Format:	Journal article
Language:	English
Published:	2012

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