Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy
<p>Nanoscale chemical mapping of newly-synthesised phospholipid molecules inside a mammalian cell is demonstrated using tip-enhanced Raman spectroscopy (TERS) for the first time using mouse pre-adipocyte cells as a model system. Newly-synthesised membrane phospholipid distribution within a pre...
| Main Authors: | , , , , |
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| Format: | Journal article |
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Royal Society of Chemistry
2017
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| _version_ | 1826275745972879360 |
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| author | Kumar, N Drozdz, M Jiang, H Santos, D Vaux, D |
| author_facet | Kumar, N Drozdz, M Jiang, H Santos, D Vaux, D |
| author_sort | Kumar, N |
| collection | OXFORD |
| description | <p>Nanoscale chemical mapping of newly-synthesised phospholipid molecules inside a mammalian cell is demonstrated using tip-enhanced Raman spectroscopy (TERS) for the first time using mouse pre-adipocyte cells as a model system. Newly-synthesised membrane phospholipid distribution within a pre-adipocyte cell is mapped with <20 nm spatial resolution, overcoming the diffraction limit of confocal Raman spectroscopy via plasmonic enhancement of Raman signals at a TERS tip-apex.</p> |
| first_indexed | 2024-03-06T23:03:28Z |
| format | Journal article |
| id | oxford-uuid:62fb90c3-4b00-43fc-846d-a50eade06d7f |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:03:28Z |
| publishDate | 2017 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:62fb90c3-4b00-43fc-846d-a50eade06d7f2022-03-26T18:09:47ZNanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:62fb90c3-4b00-43fc-846d-a50eade06d7fSymplectic Elements at OxfordRoyal Society of Chemistry2017Kumar, NDrozdz, MJiang, HSantos, DVaux, D<p>Nanoscale chemical mapping of newly-synthesised phospholipid molecules inside a mammalian cell is demonstrated using tip-enhanced Raman spectroscopy (TERS) for the first time using mouse pre-adipocyte cells as a model system. Newly-synthesised membrane phospholipid distribution within a pre-adipocyte cell is mapped with <20 nm spatial resolution, overcoming the diffraction limit of confocal Raman spectroscopy via plasmonic enhancement of Raman signals at a TERS tip-apex.</p> |
| spellingShingle | Kumar, N Drozdz, M Jiang, H Santos, D Vaux, D Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy |
| title | Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy |
| title_full | Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy |
| title_fullStr | Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy |
| title_full_unstemmed | Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy |
| title_short | Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy |
| title_sort | nanoscale mapping of newly synthesised phospholipid molecules in a biological cell using tip enhanced raman spectroscopy |
| work_keys_str_mv | AT kumarn nanoscalemappingofnewlysynthesisedphospholipidmoleculesinabiologicalcellusingtipenhancedramanspectroscopy AT drozdzm nanoscalemappingofnewlysynthesisedphospholipidmoleculesinabiologicalcellusingtipenhancedramanspectroscopy AT jiangh nanoscalemappingofnewlysynthesisedphospholipidmoleculesinabiologicalcellusingtipenhancedramanspectroscopy AT santosd nanoscalemappingofnewlysynthesisedphospholipidmoleculesinabiologicalcellusingtipenhancedramanspectroscopy AT vauxd nanoscalemappingofnewlysynthesisedphospholipidmoleculesinabiologicalcellusingtipenhancedramanspectroscopy |