Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders.

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders.

Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of ASD cases, including those with strongly acting de novo variants, in which polygenic risk is relevant. Using a novel a...

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Bibliographic Details
Main Authors: Walters, RK, Kosmicki, JA, Grove, J, Samocha, KE, Goldstein, JI, Okbay, A, Bybjerg-Grauholm, J, Werge, T, Hougaard, DM, Taylor, J, iPSYCH-Broad Autism Group, Psychiatric Genomics Consortium Autism Group, Skuse, D, Devlin, B, Anney, R, Sanders, SJ, Bishop, S, Mortensen, PB, Børglum, AD, Smith, GD, Daly, MJ, Robinson, EB
Other Authors: Wallace, S
Format: Journal article
Language:English
Published: Nature Research 2017

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