REVERBa couples the circadian clock to hepatic glucocorticoid action

REVERBa couples the circadian clock to hepatic glucocorticoid action

The glucocorticoid receptor (GR) is a major drug target in inflammatory disease. However, chronic glucocorticoid (GC) treatment leads to disordered energy metabolism, including increased weight gain, adiposity, and hepatosteatosis — all programs modulated by the circadian clock. We demonstrated that...

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Bibliographic Details
Main Authors: Caratti, G, Iqbal, M, Hunter, L, Kim, D, Wang, P, Vonslow, RM, Begley, N, Tetley, AJ, Woodburn, JL, Pariollaud, M, Maidstone, R, Donaldson, IJ, Zhang, Z, Ince, LM, Kitchen, G, Baxter, M, Poolman, TM, Daniels, DA, Stirling, DR, Brocker, C, Gonzalez, F, Loudon, AS, Bechtold, DA, Rattray, M, Matthews, LC, Ray, DW
Format: Journal article
Published: American Society for Clinical Investigation 2018

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