PARK2 mutation causes metabolic disturbances and impaired survival of human iPSC-derived neurons

PARK2 mutation causes metabolic disturbances and impaired survival of human iPSC-derived neurons

The protein parkin, encoded by the PARK2 gene, is vital for mitochondrial homeostasis, and although it has been implicated in Parkinson's disease (PD), the disease mechanisms remain unclear. We have applied mass spectrometry-based proteomics to investigate the effects of parkin dysfunction on t...

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Bibliographic Details
Main Authors:	Bogetofte, H, Jensen, P, Ryding, M, Schmidt, SI, Okarmus, J, Ritter, L, Worm, CS, Hohnholt, MC, Azevedo, C, Roybon, L, Bak, LK, Waagepetersen, H, Ryan, BJ, Wade-Martins, R, Larsen, MR, Meyer, M
Format:	Journal article
Language:	English
Published:	Frontiers Media 2019

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