OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin.

OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin.

The linear ubiquitin (Ub) chain assembly complex (LUBAC) is an E3 ligase that specifically assembles Met1-linked (also known as linear) Ub chains that regulate nuclear factor κB (NF-κB) signaling. Deubiquitinases (DUBs) are key regulators of Ub signaling, but a dedicated DUB for Met1 linkages has no...

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Bibliographic Details
Main Authors:	Keusekotten, K, Elliott, P, Glockner, L, Fiil, B, Damgaard, R, Kulathu, Y, Wauer, T, Hospenthal, M, Gyrd-Hansen, M, Krappmann, D, Hofmann, K, Komander, D
Format:	Journal article
Language:	English
Published:	2013

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