Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression

Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression

Бусад хувилбаруудыг харуулах (1)

HIF1A is a transcription factor that plays a central role for the adaptation to tissue hypoxia and for the inflammatory response of myeloid cells, including DCs. HIF1A is stabilized by hypoxia but also by TLR ligands under normoxic conditions. The underlying signaling events leading to the accumulat...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Jantsch, J, Wiese, M, Schödel, J, Castiglione, K, Gläsner, J, Kolbe, S, Mole, D, Schleicher, U, Eckardt, K, Hensel, M, Lang, R, Bogdan, C, Schnare, M, Willam, C
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2011

Ижил төстэй зүйлс

Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression.
-н: Jantsch, J, зэрэг
Хэвлэсэн: (2011)

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.
-н: Webb, J, зэрэг
Хэвлэсэн: (2009)

Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts.
-н: Mole, D, зэрэг
Хэвлэсэн: (2009)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
-н: Chan, M, зэрэг
Хэвлэсэн: (2016)

HIF-1 and HIF-2: working alone or together in hypoxia?
-н: Ratcliffe, P
Хэвлэсэн: (2007)

The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1.
-н: Schietke, R, зэрэг
Хэвлэсэн: (2010)

Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia.
-н: Johannes Kuhlicke, зэрэг
Хэвлэсэн: (2007-12-01)

HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia
-н: Flora Cimmino, зэрэг
Хэвлэсэн: (2019-02-01)

HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma
-н: J. Contenti, зэрэг
Хэвлэсэн: (2024-07-01)

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.
-н: Pollard, P, зэрэг
Хэвлэсэн: (2008)

Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2.
-н: Choudhry, H, зэрэг
Хэвлэсэн: (2014)

Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2
-н: Choudhry, H, зэрэг
Хэвлэсэн: (2013)

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
-н: Elkins, J, зэрэг
Хэвлэсэн: (2003)

HIF1α stabilization in hypoxia is not oxidant-initiated
-н: Amit Kumar, зэрэг
Хэвлэсэн: (2021-10-01)

Signalling hypoxia by HIF hydroxylases.
-н: Schofield, C, зэрэг
Хэвлэсэн: (2005)

Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.
-н: Sowter, H, зэрэг
Хэвлэсэн: (2003)

Overexpression of bHLH domain of HIF-1 failed to inhibit the HIF-1 transcriptional activity in hypoxia
-н: Fatemeh Sadeghi, зэрэг
Хэвлэсэн: (2020-06-01)

Hypoxia and HIF pathway in cancer and the placenta
-н: Macklin, P, зэрэг
Хэвлэсэн: (2017)

Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma.
-н: Morris, MR, зэрэг
Хэвлэсэн: (2009)

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.
-н: Raval, R, зэрэг
Хэвлэсэн: (2005)

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
-н: Willam, C, зэрэг
Хэвлэсэн: (2006)

Hypoxia-Inducible Factor-1 (Hif-1) in Experimental Brain Ischemia
-н: Rainald Schmidt-Kastner, зэрэг
Хэвлэсэн: (2002-01-01)

Expression of angiogenic factors and hypoxia inducible factors HIF 1, HIF 2 and CA IX in non-Hodgkin's lymphoma.
-н: Stewart, M, зэрэг
Хэвлэсэн: (2002)

Inhibition of hypoxia inducible factor (HIF) hydroxylases
-н: Conejo-Garcia, A, зэрэг
Хэвлэсэн: (2005)

HIF-1 sensor in detecting hypoxia tolerance at high altitude
-н: Shaharuddin, Shazreen, зэрэг
Хэвлэсэн: (2023)

KDM2 Family Members are Regulated by HIF-1 in Hypoxia
-н: Michael Batie, зэрэг
Хэвлэсэн: (2017-03-01)

A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas.
-н: Dahia, P, зэрэг
Хэвлэсэн: (2005)

The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability
-н: Maciej Jaśkiewicz, зэрэг
Хэвлэсэн: (2022-12-01)

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.
-н: Choudhry, H, зэрэг
Хэвлэсэн: (2014)

Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer.
-н: Koukourakis, M, зэрэг
Хэвлэсэн: (2002)

Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1(Alpha) (HIF-1(Alpha)).
-н: Thalhammer, A, зэрэг
Хэвлэсэн: (2011)

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.
-н: Wood, S, зэрэг
Хэвлэсэн: (1998)

Pericyte, but not astrocyte, hypoxia inducible factor-1 (HIF-1) drives hypoxia-induced vascular permeability in vivo
-н: Julia Baumann, зэрэг
Хэвлэсэн: (2022-01-01)

Role of hypoxia-inducible factor-1 (HIF-1) is angiogenesis and tumour biology
-н: Ratcliffe, P
Хэвлэсэн: (1999)

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.
-н: Carmeliet, P, зэрэг
Хэвлэсэн: (1998)

Hypoxia/HIF Modulates Immune Responses
-н: Yuling Chen, зэрэг
Хэвлэсэн: (2021-03-01)

Hypoxia. The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis.
-н: Muz, B, зэрэг
Хэвлэсэн: (2009)

Cycling hypoxia selects for constitutive HIF stabilization
-н: Mariyah Pressley, зэрэг
Хэвлэсэн: (2021-03-01)

Regulation of angiogenesis by hypoxia: role of the HIF system.
-н: Pugh, C, зэрэг
Хэвлэсэн: (2003)

Characterization and functional analysis of hypoxia-inducible factor HIF1α and its inhibitor HIF1αn in tilapia.
-н: Hong Lian Li, зэрэг
Хэвлэсэн: (2017-01-01)