Correlates of obesity-related chronic ventilatory failure.
<h4>Introduction</h4> <p>Only a third of obese patients develop chronic ventilatory failure. This cross-sectional study assessed multiple factors potentially associated with chronic ventilatory failure.</p> <h4>Materials/patients and methods</h4> <p>Partici...
| Κύριοι συγγραφείς: | , , |
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| Μορφή: | Journal article |
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BMJ Publishing Group
2015
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| _version_ | 1826275860014956544 |
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| author | Stradling, J Hart, N Manuel, A |
| author_facet | Stradling, J Hart, N Manuel, A |
| author_sort | Stradling, J |
| collection | OXFORD |
| description | <h4>Introduction</h4> <p>Only a third of obese patients develop chronic ventilatory failure. This cross-sectional study assessed multiple factors potentially associated with chronic ventilatory failure.</p> <h4>Materials/patients and methods</h4> <p>Participants had a body mass index (BMI) >30 kg/m^2 , with or without chronic ventilatory failure (awake arterial partial pressure of carbon dioxide >6 kPa or base excess (BE) ≥2 mmols/L). Factors investigated were grouped into domains: (1) obesity measures, (2) pulmonary function, (3) respiratory and non-respiratory muscle strength, (4) sleep study derivatives, (5) hypoxic and hypercapnic responses, and (6) some hormonal, nutritional and inflammatory measures.</p> <h4>Results</h4> <p>71 obese participants (52% male) were studied over 27 months, 52 (SD 9) years and BMI 47 (range 32–74) kg/m^2. The best univariate correlates of BE from each domain were: (1) dual-energy X-ray absorptiometry measurement of visceral fat (r=+0.50, p=0.001); (2) supine forced expiratory volume in 1 s (r=−0.40, p=0.001); (3) sniff maximum pressure (r=−0.28, p=0.02); (4) mean overnight arterial oxygen saturation (r=−0.50, p<0.001); (5) ventilatory response to 15% O2breathing (r=−0.28, p=0.02); and (6) vitamin D (r=−0.30, p=0.01). In multivariate analysis, only visceral fat and ventilatory response to hypoxia remained significant.</p> <h4>Conclusions</h4> <p>We have confirmed that in the obese, BMI is a poor correlate of chronic ventilatory failure, and the best independent correlates are visceral fat and hypoxic ventilatory response.</p> |
| first_indexed | 2024-03-06T23:05:14Z |
| format | Journal article |
| id | oxford-uuid:638b1a6b-cbb7-4b15-9cd4-b5ccdb7fb712 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:05:14Z |
| publishDate | 2015 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:638b1a6b-cbb7-4b15-9cd4-b5ccdb7fb7122022-03-26T18:13:42ZCorrelates of obesity-related chronic ventilatory failure.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:638b1a6b-cbb7-4b15-9cd4-b5ccdb7fb712Symplectic Elements at OxfordBMJ Publishing Group2015Stradling, JHart, NManuel, A <h4>Introduction</h4> <p>Only a third of obese patients develop chronic ventilatory failure. This cross-sectional study assessed multiple factors potentially associated with chronic ventilatory failure.</p> <h4>Materials/patients and methods</h4> <p>Participants had a body mass index (BMI) >30 kg/m^2 , with or without chronic ventilatory failure (awake arterial partial pressure of carbon dioxide >6 kPa or base excess (BE) ≥2 mmols/L). Factors investigated were grouped into domains: (1) obesity measures, (2) pulmonary function, (3) respiratory and non-respiratory muscle strength, (4) sleep study derivatives, (5) hypoxic and hypercapnic responses, and (6) some hormonal, nutritional and inflammatory measures.</p> <h4>Results</h4> <p>71 obese participants (52% male) were studied over 27 months, 52 (SD 9) years and BMI 47 (range 32–74) kg/m^2. The best univariate correlates of BE from each domain were: (1) dual-energy X-ray absorptiometry measurement of visceral fat (r=+0.50, p=0.001); (2) supine forced expiratory volume in 1 s (r=−0.40, p=0.001); (3) sniff maximum pressure (r=−0.28, p=0.02); (4) mean overnight arterial oxygen saturation (r=−0.50, p<0.001); (5) ventilatory response to 15% O2breathing (r=−0.28, p=0.02); and (6) vitamin D (r=−0.30, p=0.01). In multivariate analysis, only visceral fat and ventilatory response to hypoxia remained significant.</p> <h4>Conclusions</h4> <p>We have confirmed that in the obese, BMI is a poor correlate of chronic ventilatory failure, and the best independent correlates are visceral fat and hypoxic ventilatory response.</p> |
| spellingShingle | Stradling, J Hart, N Manuel, A Correlates of obesity-related chronic ventilatory failure. |
| title | Correlates of obesity-related chronic ventilatory failure. |
| title_full | Correlates of obesity-related chronic ventilatory failure. |
| title_fullStr | Correlates of obesity-related chronic ventilatory failure. |
| title_full_unstemmed | Correlates of obesity-related chronic ventilatory failure. |
| title_short | Correlates of obesity-related chronic ventilatory failure. |
| title_sort | correlates of obesity related chronic ventilatory failure |
| work_keys_str_mv | AT stradlingj correlatesofobesityrelatedchronicventilatoryfailure AT hartn correlatesofobesityrelatedchronicventilatoryfailure AT manuela correlatesofobesityrelatedchronicventilatoryfailure |