Tec family kinases in inflammation and disease.
Over the last decade, the Tec family of nonreceptor tyrosine kinases (Btk, Tec, Bmx, Itk, and Rlk) have been shown to play a key role in inflammation and bone destruction. Bruton's tyrosine kinase (Btk) has been the most widely studied due to the critical role of this kinase in B-cell developme...
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1797072296691630080 |
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| author | Horwood, N Urbaniak, A Danks, L |
| author_facet | Horwood, N Urbaniak, A Danks, L |
| author_sort | Horwood, N |
| collection | OXFORD |
| description | Over the last decade, the Tec family of nonreceptor tyrosine kinases (Btk, Tec, Bmx, Itk, and Rlk) have been shown to play a key role in inflammation and bone destruction. Bruton's tyrosine kinase (Btk) has been the most widely studied due to the critical role of this kinase in B-cell development and recent evidence showing that blocking Btk signaling is effective in ameliorating lymphoma progression and experimental arthritis. This review will examine the role of TFK in myeloid cell function and the potential of targeting these kinases as a therapeutic intervention in autoimmune disorders such as rheumatoid arthritis. |
| first_indexed | 2024-03-06T23:05:44Z |
| format | Journal article |
| id | oxford-uuid:63b99cde-10e7-4fda-bed2-203a13a28b89 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:05:44Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:63b99cde-10e7-4fda-bed2-203a13a28b892022-03-26T18:14:40ZTec family kinases in inflammation and disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:63b99cde-10e7-4fda-bed2-203a13a28b89EnglishSymplectic Elements at Oxford2012Horwood, NUrbaniak, ADanks, LOver the last decade, the Tec family of nonreceptor tyrosine kinases (Btk, Tec, Bmx, Itk, and Rlk) have been shown to play a key role in inflammation and bone destruction. Bruton's tyrosine kinase (Btk) has been the most widely studied due to the critical role of this kinase in B-cell development and recent evidence showing that blocking Btk signaling is effective in ameliorating lymphoma progression and experimental arthritis. This review will examine the role of TFK in myeloid cell function and the potential of targeting these kinases as a therapeutic intervention in autoimmune disorders such as rheumatoid arthritis. |
| spellingShingle | Horwood, N Urbaniak, A Danks, L Tec family kinases in inflammation and disease. |
| title | Tec family kinases in inflammation and disease. |
| title_full | Tec family kinases in inflammation and disease. |
| title_fullStr | Tec family kinases in inflammation and disease. |
| title_full_unstemmed | Tec family kinases in inflammation and disease. |
| title_short | Tec family kinases in inflammation and disease. |
| title_sort | tec family kinases in inflammation and disease |
| work_keys_str_mv | AT horwoodn tecfamilykinasesininflammationanddisease AT urbaniaka tecfamilykinasesininflammationanddisease AT danksl tecfamilykinasesininflammationanddisease |